Publications by authors named "A Gruber"
Canine cutaneous histiocytoma (CCH) is a tumor that originates from dermal Langerhans cells and affects particularly young dogs. The common spontaneous regression of CCH makes it an interesting model in comparative oncology research. Previous studies have indicated that anti-tumor immune responses may be involved, but details remain speculative to date.
View Article and Find Full Text PDFBackground/objectives: Microsurgical clipping has traditionally been considered a standard treatment for middle cerebral artery (MCA) aneurysms. Recently, a caseload reduction related to improved endovascular treatment options has occurred in cerebrovascular neurosurgery. Therefore, studies that report the clinical and radiological outcomes after clipping are highly warranted.
View Article and Find Full Text PDFBackground: Approximately half of all human cancers harbour mutations in the p53 gene, leading to the generation of neomorphic p53 mutant proteins. These mutants can exert gain-of-function (GOF) effects, potentially promoting tumour progression. However, the clinical significance of p53 GOF mutations, as well as the selectivity of individual variants, remains controversial and unclear.
View Article and Find Full Text PDFSimulated synapse loss induces depression-like behaviors in deep reinforcement learning.
Front Comput Neurosci
November 2024
Article Synopsis
- - Deep Reinforcement Learning (DRL) is used to simulate how biological agents learn based on rewards, and researchers modified DRL to mimic the effects of dendritic spine loss seen in major depressive disorder (MDD).
- - This simulated spine loss led to various MDD-like behaviors in the AI, such as loss of pleasure (anhedonia), increased impatience for rewards (temporal discounting), and changes in how the AI explores or exploits options.
- - The findings suggest that MDD may be more related to reduced brain connectivity rather than just chemical imbalances, indicating potential treatment avenues that focus on enhancing brain plasticity and synapse formation.