Publications by authors named "A Gronkowska"
HLA-inferred extended haplotype disparity level is more relevant than the level of HLA mismatch alone for the patients survival and GvHD in T cell-replate hematopoietic stem cell transplantation from unrelated donor.
Hum Immunol
June 2018
Article Synopsis
- Unrelated hematopoietic stem cell transplantation (HSCT) poses serious risks like graft versus host disease (GvHD) and mortality, which are heightened by differences in HLA (human leukocyte antigen) between donors and recipients.
- A study involving 889 patients revealed that higher levels of Ehp (extended MHC haplotype) mismatch lead to increased incidences of GvHD and mortality, independent of the HLA mismatch level.
- Patients with a single HLA mismatch but double Ehp disparity showed significantly lower overall survival rates and higher non-relapse mortality compared to those with only one Ehp mismatch, suggesting that Ehp matching is crucial in HSCT outcomes.
of specific anti-HHV-6 antibodies in IgM and IgG classes and viral DNA. Quantitative real-time PCR assay was also used to determine viral load in alloHSCT recipients in plasma samples. Results: All individuals from studied group have not IgM antibodies against-HHV-6 prior transplantation.
View Article and Find Full Text PDFThe present study aimed to assess the impact of the CXCL12 gene polymorphism (rs1801157) on clinical outcome of hematopoietic stem cell transplantation from unrelated donors. Toxic complications were less frequent among patients transplanted from donors carrying the CXCL12-3'-A allele (42/79 vs. 105/151, p=0.
View Article and Find Full Text PDFSome cancers treated with allogeneic hematopoietic stem cell transplantation (HSCT) are sensitive to natural killer cell (NK) reactivity. NK function depends on activating and inhibitory receptors and is modified by NK education/licensing effect and mediated by coexpression of inhibitory killer-cell immunoglobulin-like receptor (KIR) and its corresponding HLA I ligand. We assessed activating KIR (aKIR)-based HLA I-dependent education capacity in donor NKs in 285 patients with hematological malignancies after HSCT from unrelated donors.
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