Publications by authors named "A Gromotowicz-Poplawska"
Article Synopsis
- FDA-approved anticoagulants can increase bleeding risks, including serious intracranial hemorrhages, but the specific effectiveness and safety of sulfonate polymers as alternatives have not been thoroughly studied.
- Researchers synthesized and evaluated various sulfonated copolymers, finding that PSSS-based copolymers showed stronger anticoagulant effects compared to PAMPS-based ones, with the effectiveness influenced by sulfonate concentration and molecular weight.
- The PEG-PSSS copolymer demonstrated significant anticoagulant activity in animal models and can be reversed by Heparin Binding Copolymer (HBC), targeting specific factors in the blood coagulation process, indicating potential for use in medical applications related to blood contact.
Platelet endothelial cell adhesion molecule 1 (PECAM-1) is considered an antiplatelet molecule. Previously, we introduced a new parameter called the PECAM-1/thrombus ratio, which indicates the proportion of PECAM-1 in the thrombus and provides a precise description of human platelet activity (in vitro). The aim of this study was to determine whether the PECAM-1/thrombus ratio could serve as a predictive factor for bleeding events during off-pump coronary artery bypass grafting (OPCAB).
View Article and Find Full Text PDFSodium-glucose cotransporter 2 inhibitors (SGLT2i) are antihyperglycemic drugs that decrease mortality from cardiovascular diseases. However, their effects on hemostasis in the cardioprotective effects have not been evaluated. Therefore, the effects of canagliflozin (CANA, 100 mg/kg, p.
View Article and Find Full Text PDFThe aim of this study was to evaluate the effect of acute aldosterone (ALDO) administration on the vascular permeability of skin. ALDO was injected intradermally into rats, and vascular permeability was measured. Eplerenone (EPL), a selective mineralocorticoid receptor (MR) antagonist, was used.
View Article and Find Full Text PDFThe aim of the study was to investigate in vivo whether the application of immobilized superoxide dismutase (SOD) and catalase (CAT) could enhance DNA repairing systems and reduce level of CPD (cyclobutane pyrimidine dimers) and 6-4PP ((6-4) pyrimidine-pyrimidone photoproducts), and whether the immobilization on gold (AuNPs) and silver (AgNPs) nanoparticles affects the outcome. The study presents secondary analysis of our previous research. Three-day application of SOD and CAT in all forms of solution decreased the levels of CPD and 6-4PP boosted by UV irradiation.
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