Pyloric type metaplasia (PYME) as evidence of chronic mucosal damage, is one of the main histopathological findings for diagnosing Crohn's Disease (CD) in terminal ileum biopsies, according to the latest guidelines but still frequently underdiagnosed in routine pathology. Foveolar metaplasia (FOME) changes in mucosa, another aspect of the chronic post -inflammatory Ulcer Associated Cell Lineage (UACL), have only been reported in a few cases. However, their clinical significance has not been investigated in depth except in pouchitis.
View Article and Find Full Text PDFThe left umbilical vein is lodged on the fissure of the round ligament of the liver, from umbilicus to portal vein, just on the inferior margin of the falciform ligament. We report an anomalous course of the umbilical vein in a 39-week-old deceased male fetus, also exhibiting fetal thrombotic vasculopathy (FTV). In the present case, the umbilical vein entered the liver through a tunnel on its anterior part of the diaphragmatic surface, close to the lower free edge of the liver and next to the falciform ligament.
View Article and Find Full Text PDFPretibial myxedema (PM) is a rare extrathyroidal manifestation of Graves' disease (GD), usually during the hyperthyroid state, coexisting with orbitopathy. We describe a rare case of a biopsy-proven PM in a euthyroid patient, without history of GD or Hashimoto's thyroiditis. Assessment of commonly reported thyroid autoantibodies, such as thyroid peroxidase and thyroglobulin autoantibodies, thyroid stimulating immunoglobulins and thyroid binding inhibitory immunoglobulins, was negative.
View Article and Find Full Text PDFBackground And Objectives: Basosquamous carcinoma (BSC) is a rare, biologically aggressive tumor. This cross-sectional study aims to define risk factors for subclinical nodal metastasis in primary BSC, and identify the patients who would benefit from routine sentinel node biopsy (SLNB) as part of the initial management.
Methods: A total of 142 patients, with histologically proven BSC without palpable lymph nodes, underwent SLNB after the initial excision.