Publications by authors named "A Grange"
[Human papillomaviruses : origin, oncogenic factors and markers for cervical cancer screening].
Virologie (Montrouge)
December 2024
Article Synopsis
- Human Papillomaviruses (HPV) have co-evolved with humans, being the main cause of cervical cancer, particularly HPV16, which is the most oncogenic high-risk type.
- The E6/E7 proteins of high-risk HPVs, especially HPV16, are critical for cervical cancer development as they interact with important cellular proteins like p53 and pRb, influencing viral persistence and oncogenesis.
- New methods for analyzing HPV mutations and alterations in the viral genome could enhance cervical cancer screening processes in France.
Article Synopsis
- Covid-19 led to unprecedented redeployment of nurses, prompting a need to understand how they managed this experience and its impact on their well-being and job performance.
- A study involving 62 nurses from diverse NHS Trusts in England used interviews and surveys to analyze their experiences over two years, focusing on their psychological distress, burnout, and turnover intentions.
- The research revealed three distinct "sensemaking journeys" regarding the nurses' identities, with those maintaining strong organizational identification experiencing better overall outcomes compared to those whose organizational connection weakened.
Background: The mass redeployment of nurses was critical across countries necessitated by the acute health impact of Covid-19. Knowledge was limited regarding how to manage nurse redeployment or the impact that redeployment might have. Redeployment continues, particularly in response to the current staffing crisis and surges such as winter pressures.
View Article and Find Full Text PDFBackground: Critical care nurses (CCNs) are routinely exposed to highly stressful situations, and at high-risk of suffering from work-related stress and developing burnout. Thus, supporting CCN wellbeing is crucial. One approach for delivering this support is by preparing CCNs for situations they may encounter, drawing on evidence-based techniques to strengthen psychological coping strategies.
View Article and Find Full Text PDFBackground: Identifying the causes of Acute Undifferentiated Febrile Illness (AUFI) is key to improve the management of returning travellers with fever. We evaluated a BioFire®FilmArray® prototype panel of multiplex nucleic acid amplification tests (NAAT) targeting different relevant pathogens in travellers returning with fever.
Methods: Prospective, multicentre study to evaluate a prototype panel in whole blood samples of adult international travellers presenting with AUFI in three European travel Clinics/Hospitals (November 2017-November 2019).