Elevated cannabinoid 1 receptor mRNA is linked to eating disorder related behavior and attitudes in females with eating disorders.

Objective: The endocannabinoid system is involved in the regulation of appetite, food intake and energy balance.

Methods: To study possible differences in CB(1) and CB(2) mRNA expression in eating disorders, 20 patients with anorexia nervosa (AN), 23 with bulimia nervosa (BN) and 26 healthy women were enrolled into the trial (Homocysteine and Eating Disorders, HEaD).

Results: We found significantly higher levels of CB(1) receptor mRNA in the blood of patients with AN (DeltaCT: -3.

Alpha-synuclein mRNA levels correspond to beck depression inventory scores in females with eating disorders.

Alpha-synuclein (alpha-Syn) is a neuronal protein involved in the regulation of brain serotonin and dopamine levels. We analyzed the peripheral expression of alpha-Syn mRNA and Beck Depression Inventory scores in female patients suffering from anorexia nervosa (n = 18) or bulimia nervosa (n = 24). We found a significant positive association between alpha-Syn mRNA expression and the total scores of the Beck Depression Inventory (linear regression; R(2) = 0.

[Closure of the duodenal stump in low ulcers penetrating the pancreas].

The paper reports on a method of closing the duodenal stump, with maintenance of the ulcerous crater by sectioning the duodenum at the level of penetration. At closure, the ventral duodenum wall is sutured at the arterio-superior circumference of the sclerous ring of the penetration with nonabsorbable suture. The in-pocketing is achieved by one or two bursae.