Publications by authors named "A Gough"

Background: Anxiety disorders are prevalent amongst older adults and negatively impact their quality-of-life and health. Anxiety disorders often go undetected or are misattributed to age-related changes. The aim of this systematic review of reviews, was to synthesize existing evidence on risk factors associated with anxiety in older adults to improve opportunities for early detection and intervention.

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Background: C-reactive protein (CRP) and high-sensitivity C-reactive protein (hsCRP) are measures of inflammation used in diagnosis, to guide treatment decisions, and in disease prediction. Variability in measured CRP and hsCRP may affect their clinical utility but estimates of within-subject variability are based on limited data.

Methods: A systematic review and meta-analysis was performed to estimate longitudinal within-subject variability of CRP and hsCRP over any time period.

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  • The study suggests that insulin resistance in the liver is a key factor leading to dysfunction in pancreatic islets, which is linked to Type 2 Diabetes Mellitus (T2DM) and Metabolic Associated Steatotic Liver Disease (MASLD).
  • Researchers developed a microphysiological system combining liver and pancreatic models to better understand how these organ dysfunctions relate to each other. This system allows for the investigation of changes that occur when metabolic syndrome is present.
  • Results showed that under metabolic syndrome conditions, the liver-pancreas system exhibited altered insulin secretion and signaling, indicating a direct connection between liver issues and islet dysfunction, which could help in developing personalized treatment strategies for affected patients.
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  • - MASLD is a global health issue affecting around 30% of the population, caused by a mix of genetics, lifestyle, and environmental factors, posing challenges for treatment development due to patient variability.
  • - Creating effective therapeutic models is difficult because existing systems and animal models fail to fully reflect the complexities of MASLD progression, prompting the need for more precise experimental approaches.
  • - The study utilized a liver acinus microphysiology system (LAMPS) with patient-derived cells to explore the effects of the PNPLA3 genetic variant on MASLD and tested the drug resmetirom, revealing significant changes in liver cell behavior indicative of disease progression.
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  • * Out of 112 respondents, which included both surgeons and hand therapists, the study found significant variability in surgical decision-making and imaging practices, with most centers favoring ligament reconstruction using a bone anchor.
  • * Findings suggest that there is inconsistency in the treatment approaches for UCL ruptures and a strong interest among medical professionals for future clinical trials to standardize management practices.
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