Saccharomyces yeast postbiotics mitigate mucosal damages from F18 Escherichia coli challenges by positively balancing the mucosal microbiota in the jejunum of young pigs.

Background: Enterotoxigenic Escherichia coli (E. coli) is one of the most prevalent causes of diarrhea in young animals. Postbiotics derived from yeast have the potential to positively influence the mucosal microbiota in the jejunum, therefore it was hypothesized that Saccharomyces yeast postbiotics could enhance the microbiota and mucosal immune response in the jejunum, mitigating the effects of infection with enterotoxigenic E.

Granulomatosis with polyangiitis mimicking multisystem pyoderma gangrenosum: A case report.

Granulomatosis with polyangiitis, a type of small-medium vessel vasculitis, can pose diagnostic challenges due to its diverse clinical manifestations. We present a case that mimicked multisystem pyoderma gangrenosum with cutaneous ulceration, renal sparing, and antineutrophil cytoplasmic antibody negativity. Although antineutrophil cytoplasmic antibody is positive in approximately 90% of cases of granulomatosis with polyangiitis, its negativity should not exclude the diagnosis.

Optimising Control Device Luring Strategies for Invasive Predator Control: A Modelling Approach.

Invasive predators pose a serious threat to native biodiversity, with trapping being one of several methods developed to manage and monitor their populations. Many individuals in these predator populations have been found to display trap-shyness, which hinders eradication and results in inaccurate estimates of population size. Lures are used to help overcome trap-shyness by increasing the probability of interaction with the device, but the extent of trap-shyness in wild populations, and the best timing for the introduction of a new lure or combination of lures, are uncertain.

Phosphorylation Toggles the SARS-CoV-2 Nucleocapsid Protein Between Two Membrane-Associated Condensate States.

The SARS-CoV-2 Nucleocapsid protein (N) performs several functions during the viral lifecycle, including transcription regulation and viral genome encapsulation. We hypothesized that N toggles between these functions via phosphorylation-induced conformational change, thereby altering N interactions with membranes and RNA. We found that phosphorylation changes how biomolecular condensates composed of N and RNA interact with membranes: phosphorylated N (pN) condensates form thin films, while condensates with unmodified N are engulfed.