Publications by authors named "A Gorga"
Article Synopsis
- The rapid growth of medical apps has changed how health care is delivered, allowing easy access to personalized health data for patients and providers, but effectiveness and safety concerns have emerged, challenging the reliance on randomized controlled trials (RCTs) for evaluation and regulation.
- This study explores alternative evaluation methods beyond RCTs for medical apps by analyzing insights from a focus group of public health experts and assessing current regulations in Italy, Germany, Canada, and Australia.
- Findings highlight the limitations of RCTs in evaluating digital health interventions and suggest that there are potentially more effective approaches for ensuring the quality and safety of medical apps.
Sertoli cells provide structural and nutritional support for germ cell development. They actively metabolize glucose and convert it into lactate, which is an important source of energy for germ cells. They also oxidize fatty acids (FA), stored as triacylglycerides (TAGs) within lipid droplets (LD), to fulfill their own energy requirements.
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- The study aimed to investigate the effects of glyphosate (G) and Roundup (R) on male fertility by treating juvenile male rats and assessing the impact on blood-testis barrier function and sperm production.
- No significant differences in body and testis weight were found, but treated groups exhibited disorganized testis histology and increased blood-testis barrier permeability.
- Ultimately, the findings indicated that juvenile exposure to G or R did not have lasting negative effects on adult male fertility, as normal spermatogenesis and sperm quality were maintained in treated rats.
Background: The direct correlation between Sertoli cell number and sperm production capacity highlights the importance of deciphering external factors that modify Sertoli cell proliferation. A growing body of evidence in vitro suggests that metformin, the main pharmacological agent for type 2 diabetes treatment in children, exerts anti-proliferative effects on Sertoli cells.
Objective: The aims of this study were to investigate the effect of metformin administration during postnatal period on Sertoli cell proliferation and on cell cycle regulators expression and to analyze the impact of this treatment on the sperm production capacity in adulthood.
Roundup (R), a formulation that contains glyphosate (G) as the active ingredient, is a commonly used nonselective herbicide that has been proposed to affect male fertility. It is well known that an adequate Sertoli cell function is essential to maintain germ cell development. The aim of the present study was to analyze whether G and R are able to affect Sertoli cell functions, such as energy metabolism and blood-testis barrier (BTB) integrity.
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