YAP-driven malignant reprogramming of oral epithelial stem cells at single cell resolution.

Tumor initiation represents the first step in tumorigenesis during which normal progenitor cells undergo cell fate transition to cancer. Capturing this process as it occurs in vivo, however, remains elusive. Here we employ spatiotemporally controlled oncogene activation and tumor suppressor inhibition together with multiomics to unveil the processes underlying oral epithelial progenitor cell reprogramming into tumor initiating cells at single cell resolution.

A comparative evaluation of dark fermentative bioreactor configurations for enhanced hydrogen production.

Energy from renewable resources has been growing in popularity, which ultimately helps reduce emissions of greenhouse gases (GHGs) and contaminants. Since hydrogen (H) has a higher combustion production of energy than hydrocarbon fuels, it has been identified as a clean, sustainable, and environmentally friendly energy source. There are several benefits to producing biohydrogen (bioH) from renewable sources, including lower cost and increased sustainability.

Antiviral and cytotoxic activities and chemical profiles of two species of from Türkiye.

is an important genus of the family Pinaceae, with about 50 species found in the highlands of Asia, Europe, North Africa, and North and Central America. The principal aim of the present work was to investigate the chemical content and biological potential of the resin and cone from subsp. and subsp.