Publications by authors named "A Goodson"
Rapid and automated design of two-component protein nanomaterials using ProteinMPNN.
Proc Natl Acad Sci U S A
March 2024
The design of protein-protein interfaces using physics-based design methods such as Rosetta requires substantial computational resources and manual refinement by expert structural biologists. Deep learning methods promise to simplify protein-protein interface design and enable its application to a wide variety of problems by researchers from various scientific disciplines. Here, we test the ability of a deep learning method for protein sequence design, ProteinMPNN, to design two-component tetrahedral protein nanomaterials and benchmark its performance against Rosetta.
View Article and Find Full Text PDFArticle Synopsis
- - Venezuelan equine encephalitis virus (VEEV) causes sporadic outbreaks and lacks FDA-approved vaccines or treatments, prompting the need for reliable animal models for testing medical countermeasures.
- - Current studies focus on the cynomolgus macaque (CM) model at high VEEV doses, revealing that the infectious dose for two VEEV subtypes is significantly lower than previously thought.
- - Researchers propose using a lower challenge dose of 1.0 × 10 PFU in CM models to consistently demonstrate signs of infection, aiding in the evaluation of potential medical countermeasures effectively.
Citation for the 2022 BAOMS Down Surgical Prize - Peter Brennan.
Br J Oral Maxillofac Surg
October 2023
This study examined the direct effect of "classic rape" characteristics, and how they were moderated by rape myth endorsement, on the likelihood of arrest, perceived district attorney charge acceptance, and perceived suspect conviction using a formal rape disclosure among a sample of 468 police participants from a sizeable municipal law enforcement agency in one of the fifth largest and most diverse U.S. cities.
View Article and Find Full Text PDF