Publications by authors named "A Gonzalez-Villalva"
Evaluation of genotoxic damage, production reactive oxygen and nitrogen species in Plasmodium yoelii yoelii exposed to sodium metavanadate.
Environ Toxicol Pharmacol
June 2024
Malaria represents the greatest global health burden among all parasitic diseases, with drug resistance representing the primary obstacle to control efforts. Sodium metavanadate (NaVO) exhibits antimalarial activity against the Plasmodium yoelii yoelii (Pyy), yet its precise antimalarial mechanism remains elusive. This study aimed to assess the antimalarial potential of NaVO, evaluate its genotoxicity, and determine the production of reactive oxygen and nitrogen species (ROS/RNS) in Pyy.
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- The non-ciliated bronchiolar cell, known as the "club cell," plays a crucial role in the airway epithelium, primarily located in the bronchioles of humans and found prominently in rodents.
- Club cells serve multiple functions, acting as regulatory cells in lung inflammation and as stem cells for lung epithelial regeneration.
- This review aims to explore club cell structure and function under normal and disease conditions to enhance the understanding of their significance in the respiratory system.
Article Synopsis
- The non-ciliated bronchiolar cell (NCBC) in the lungs defends against harmful substances and increases mucin and CC16 protein production in response to exposure to toxins.
- A study explored how male and female CD-1 mice reacted differently to inhaling vanadium (V) over four weeks, finding that both sexes experienced hyperplasia and NCBC sloughing but had varying levels of mucosecretory metaplasia.
- Results showed increased expression of CC16 in both genders, but male mice exhibited more severe changes, indicating significant differences in susceptibility to toxic inhalants based on sex.
Toxic Effects of Inhaled Vanadium Attached to Particulate Matter: A Literature Review.
Int J Environ Res Public Health
August 2021
Article Synopsis
- Environmental pollution, recognized as a major health risk by the World Health Organization, affects all income levels and highlights the dangers of suspended particulate matter, especially those containing vanadium emitted from fossil fuel combustion.
- The literature review focuses on the toxic effects of vanadium when inhaled, based on studies using a mouse model that reveal harmful impacts across various bodily systems.
- Research indicates vanadium exposure leads to serious health issues, including immunotoxicity and neurotoxicity, emphasizing the need for informed environmental policies to protect public health.
The aim of this report was to evaluate the morphological and biochemical changes in the liver by the inhalation of vanadium and consumption of sweetened beverages in a subchronic murine model. Forty CD-1 male mice were randomly divided into four groups: control, vanadium (V), sucrose 30% (S), and vanadium-sucrose (V + S). V was inhaled (1.
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