Publications by authors named "A Gonzalez-Pineiro"
The diversity of patients with malignant pleural effusion (MPE) due to non-small cell lung cancer (NSCLC) as well as the variability in mutations makes it essential to improve molecular characterization. Describe clinical, pathological, and molecular characteristics MPE in a Caucasian population. Retrospective study of patients with NSCLC diagnosis who had undergone a molecular study from 1 January 2018-31 December 2022.
View Article and Find Full Text PDFArticle Synopsis
- Blood eosinophil count (BEC) is used for evaluating T2 inflammation in severe asthma, but its connection to tissue changes remains unclear; bronchial biopsy may clarify this issue with a standardized pathological scoring system.
- A systematic evaluation of various tissue characteristics (like eosinophilic count and goblet cell hyperplasia) was conducted on biopsies from severe uncontrolled asthma patients, showing strong agreement among pathologists and significant correlations between BEC, tissue eosinophil count (TEC), and fractional exhaled nitric oxide (FeNO).
- The study concludes that a standardized assessment of bronchial biopsy can enhance the understanding and classification of severe uncontrolled asthma, especially in patients undergoing treatment with oral corticosteroids.
Introduction: The ROS1 gene rearrangement has become an important biomarker in NSCLC. The College of American Pathologists/International Association for the Study of Lung Cancer/Association for Molecular Pathology testing guidelines support the use of ROS1 immunohistochemistry (IHC) as a screening test, followed by confirmation with fluorescence in situ hybridization (FISH) or a molecular test in all positive results. We have evaluated a novel anti-ROS1 IHC antibody (SP384) in a large multicenter series to obtain real-world data.
View Article and Find Full Text PDFIntroduction: Diffuse idiopathic pulmonary neuroendocrine cell hyperplasia (DIPNECH) is a rare disorder characterized by a proliferation of neuroendocrine cells within the lung. It is classically described as a disease with persistent cough, dyspnea and wheezing in non-smoker middle aged females. CT of the chest reveals diffuse air trapping with mosaic pattern.
View Article and Find Full Text PDF