Publications by authors named "A Gonzalez-Hernandez"
Paclitaxel (PCX) based treatments, commonly used to treat breast, ovarian and lung cancers, have the highest incidence of chemotherapy-induced neuropathic pain, affecting from 38 to 94 % of patients. Unfortunately, analgesic treatments are not always effective for PCX-induced neuropathic pain (PINP). This study aimed to evaluate the antinociceptive effect of clavulanic acid (CLAV), a clinically used β-lactam molecule, in both therapeutic and preventive contexts in mice with PINP.
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- * This systematic review included 22 studies focusing on elderly patients with clinical diagnoses of strokes, assessing how EPC levels relate to clinical outcomes.
- * Higher EPC levels were associated with better functional outcomes, reduced infarct growth, and lower recurrence risk in ischemic strokes, suggesting that EPC quantification could be valuable in evaluating stroke prognosis.
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- Structural income inequality, defined as the uneven distribution of income across regions, affects brain dynamics and functions more significantly than individual factors like age or education.
- This study used EEG signals from 1,394 healthy participants across 10 countries to explore how structural inequality predicts various brain activity metrics, revealing a connection between socioeconomic conditions and neural functioning.
- Results show that higher structural income inequality is associated with lower brain signal complexity, increased random neural activity, and reduced power in certain brain wave frequencies, suggesting the need for a broader understanding of how social factors influence brain health.
Hypothalamic cerebrospinal fluid-contacting neurons project to the rostral agranular insular cortex: An immunofluorescence and ultrastructural analysis in the rat.
Eur J Neurosci
November 2024
Cerebrospinal fluid-contacting neurons (CSF-cNS) are considered mechanoreceptors and chemoreceptors involved in detecting changes in CSF circulation. However, considering that recent data suggest that this type of cell could exert an active response when an external stimulus is sensed, identification of CSF-cNS may be relevant. In this regard, some data suggest that a neuronal connection exists between the ventral region of the hypothalamic paraventricular nucleus (PVN) and rostral agranular insular cortex (RAIC); indeed, a potential CSF-cNS is hypothesized.
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- Migraine is a complicated disorder, with calcitonin gene-related peptide (CGRP) playing a key role in its understanding and the development of new treatments like gepants and monoclonal antibodies, which are effective and safe for patients.
- A narrative review investigated CGRP's role in migraines and analyzed the effects of CGRP-targeted medications regarding how they work and how the body processes them.
- While current CGRP medications show effectiveness, they have limitations, like side effects and varying efficacy among patients; some patients' migraines may persist due to the complexity of migraine mechanisms and medication properties.