Exosomes derived from tumor adjacent fibroblasts efficiently target pancreatic tumors.

The application of extracellular vesicles, particularly exosomes (EXs), is rapidly expanding in the field of medicine, owing to their remarkable properties as natural carriers of biological cargo. This study investigates utilization of exosomes derived from stromal cells of tumor adjacent normal tissues (NAF-EXs) for personalized medicine, which can be derived at the time of diagnosis by endoscopic ultrasound. Herein, we show that exosomes (EXs) derived from NAFs demonstrate differential bio-physical characteristics, efficient cellular internalization, drug loading efficiency, pancreatic tumor targeting and delivery of payloads.

English-speaking and Spanish-speaking domestic violence perpetrators: an MMPI-2 assessment.

The use of assessments to characterize domestic violence perpetrators continues to develop with an emphasis on increasing the effectiveness of domestic violence interventions. The present study examines and compares Minnesota Multiphasic Personality Inventory (MMPI)-2 responses from 41 English-speaking and 48 Spanish-speaking men who were in court-mandated domestic violence treatment programs. Data are analyzed on all validity, clinical, supplementary, and content scales using composite means and cluster analyses.

Natural infection by gastrointestinal and bronchopulmonary nematodes in mouflons (Ovis musimon) and their response to netobimin treatment.

Gastrointestinal and bronchopulmonary nematode infections and the efficacy of netobimin (Hapasil) were analyzed by way of fecal examination in 10 female mouflons (Ovis musimon), in central Spain, February 1993. Before treatment all 10 mouflons had Trichostrongylus axei, Teladorsagia circumcincta and Marshallagia spp.; sic had Nematodirus spp.

Coccidial infection in mouflon, Ovis musimon, in central Spain.

From February to September 1993, ten adult female mouflons (Ovis musimon) and their five offspring from central Spain were examined weekly for coccidial infection. All adult mouflons had Eimeria spp. infections with mean (+/- SD) intensity of 1,869 (+/- 1,264) oocysts per gram of feces the day of capture, increasing progressively during the first two months in captivity and later returning to the initial values (1,869 +/- 1,547).