Postoperative lymphopaenia as a risk factor for postoperative infections in cancer surgery: A prospective multicentre cohort study (the EVALYMPH study).

Background: Stress due to surgical trauma decreases postoperative lymphocyte counts (LCs), potentially favouring the occurrence of postoperative infections (PIs).

Objectives: We aimed to determine whether postoperative lymphopaenia following thoracic or gastrointestinal cancer surgery is an independent risk factor for PIs and to identify modifiable factors related to anaesthesia and surgical procedures that might affect its occurrence.

Study Design: The EVALYMPH study was a prospective, multicentre cohort study with a 30-day patient follow-up.

A novel STPA approach to software safety and security in autonomous maritime systems.

With higher autonomy in maritime systems, tasks and responsibilities are moved from the human operator to software, increasing the complexity and the importance of safe and reliable functionality. Software failures, however, may be introduced from the early life cycle phases intentionally or unintentionally, and these must therefore be mitigated by safe and secure design approaches. A challenge is that existing methods are not particularly well-suited for analyzing software risks.

Plasma transfusion in liver transplantation: a randomized, double-blind, multicenter clinical comparison of three virally secured plasmas.

Background: The clinical equivalence of plasma treated to reduce pathogen transmission and untreated plasma has not been extensively studied. A clinical trial was conducted in liver transplant recipients to compare the efficacy of three plasmas.

Study Design And Methods: A randomized, equivalence, blinded trial was performed in four French liver transplantation centers.

The effect of erythropoietin on allogeneic blood requirement in patients undergoing elective liver resection: a model simulation.

Unlabelled: We investigated whether recombinant human erythropoietin (rHuEPO) administration would reduce red blood cell (RBC) transfusion requirements in patients undergoing elective liver resection. We retrospectively investigated 200 patients undergoing elective liver resection. Factors likely to predict perioperative RBC transfusion were studied using a logistic regression analysis.

Remifentanil-propofol vs. sufentanil-propofol: optimal combinations in clinical anesthesia.

Background: Two opioid regimens, computer-simulated to provide optimal general anesthesia in combination with propofol, were compared using clinical criteria.

Methods: Fifty patients undergoing thyroid surgery were blindly, prospectively and randomly allocated to receive either (a) i.v.