Role of inducible nitric oxide (iNOS) and nitrosative stress in regulating sex differences in secondary lymphedema.

Secondary lymphedema is a common complication following surgical treatment of solid tumors. Although more prevalent in women due to higher breast cancer rates, men also develop lymphedema, often with more severe manifestations. Despite these differences in clinical presentation, the cellular mechanisms underlying sex differences are poorly understood.

Intrasession repeatability and interobserver reproducibility of ICP Tearscope measurements of tear meniscus height and non-invasive breakup time.

Purpose: To examine intrasession repeatability and interobserver reproducibility of tear meniscus height (TMH) and non-invasive tear breakup time (NIBUT) measurements provided by ICP Tearscope, and their agreement with Keratograph 5 M measurements in persons with and without dry eye.

Methods: Participants were 48 individuals with dry eye disease (DED) and 44 healthy controls. To determine intrasession repeatability, two consecutive TMH and NIBUT measurements were carried out by a single experienced examiner using ICP Tearscope.

Society of Surgical Oncology Breast Disease Site Working Group Statement on Bilateral Risk-Reducing Mastectomy: Indications, Outcomes, and Risks.

Bilateral risk-reducing mastectomy (BRRM) is the surgical removal of both breasts to reduce the risk of cancer. In this Society of Surgical Oncology position statement, we review the literature addressing the indications, outcomes, and risks of BRRM to update the society's 2017 statement. We held a virtual meeting to outline key topics and conducted a literature search using PubMed to identify relevant articles.

Nodal Burden and Oncologic Outcomes in Patients With Residual Isolated Tumor Cells After Neoadjuvant Chemotherapy (ypN0i+): The OPBC-05/ICARO Study.

Purpose: The nodal burden of patients with residual isolated tumor cells (ITCs) in the sentinel lymph nodes (SLNs) after neoadjuvant chemotherapy (NAC) (ypN0i+) is unknown, and axillary management is not standardized. We investigated rates of additional positive lymph nodes (LNs) at axillary lymph node dissection (ALND) and oncologic outcomes in patients with ypN0i+ treated with and without ALND.

Methods: The Oncoplastic Breast Consortium-05/ICARO cohort study (ClinicalTrials.