Discovery of a Pseudomonas aeruginosa-specific small molecule targeting outer membrane protein OprH-LPS interaction by a multiplexed screen.

The surge of antimicrobial resistance threatens efficacy of current antibiotics, particularly against Pseudomonas aeruginosa, a highly resistant gram-negative pathogen. The asymmetric outer membrane (OM) of P. aeruginosa combined with its array of efflux pumps provide a barrier to xenobiotic accumulation, thus making antibiotic discovery challenging.

The relationships of serum vitamin D concentration with linear speed and change of direction performance in soccer players.

The aim of the study was to establish whether the level of 25 hydroxyvitamin D (25(OH)D) in serum has an influence on speed (m/s) and change of direction (COD, s) performance. Twenty male soccer players from the top league participated in the study. All subjects were evaluated for the serum concentration of 25(OH)D at the beginning of the preseason.

Effects of Extrinsic and Intrinsic Motivation on Selective Activation of Shoulder Girdle Muscles During the Barbell Bench Press Exercise.

This study aimed to investigate the effects of intrinsic and extrinsic motivation on selective muscle activation of the shoulder girdle during the barbell bench press. Specifically, this research focused on how attentional focus on individual muscles, such as the anterior deltoid (AD), pectoralis major (PM), and triceps brachii long (TBL), could influence their electromyographic (EMG) activity during the exercise. : Twelve male participants, with at least five years of strength training experience, performed bench press exercises under two conditions: with extrinsic motivation (no specific focus on muscle activity) and with intrinsic motivation (internal focus on specific muscles).

Effects of an 8-week pre-season targeted training on sprinting performance, agility and lower limb muscular asymmetries in elite soccer players.

The purpose of this study was to determine the effects of an 8 week targeted training program on speed, agility, and muscle asymmetries in soccer players. 32 elite soccer players were recruited for the study. Their age, body mass, and body height were 25.