Cross-species modeling of plant genomes at single nucleotide resolution using a pre-trained DNA language model.

Interpreting function and fitness effects in diverse plant genomes requires transferable models. Language models (LMs) pre-trained on large-scale biological sequences can learn evolutionary conservation and offer cross-species prediction better than supervised models through fine-tuning limited labeled data. We introduce PlantCaduceus, a plant DNA LM based on the Caduceus and Mamba architectures, pre-trained on a curated dataset of 16 Angiosperm genomes.

The butterfly effect on glioblastoma: is volumetric extent of resection more effective than biopsy for these tumors?

A subset of patients with glioblastoma (GBM) have butterfly GBM (bGBM) that involve both cerebral hemispheres by crossing the corpus callosum. The prognoses, as well as the effectiveness of surgery and adjuvant therapy, are unclear because studies are few and limited. The goals of this study were to: (1) determine if bGBM have worse outcomes than patients with non-bGBM, (2) determine if surgery is more effective than biopsy, and (3) identify factors independently associated with improved outcomes for these patients.

Incidence of sacral fractures and in-hospital postoperative complications in the United States: an analysis of 2002-2011 data.

Study Design: Retrospective study of an administrative database.

Objective: To estimate the incidence of sacral fractures in the United States and report short-term outcomes after their surgical management.

Summary Of Background Data: The incidence of sacral fractures in the United States is currently unknown, and these lesions have been associated with significant morbidity after their surgical management.

Spontaneous regression of sequestrated lumbar disc herniations: Literature review.

Lumbar disc herniations (LDH) may regress with conservative management; however, this phenomenon is poorly understood for the sequestrated subtype of LDH. We present one of the first comprehensive literature reviews specifically addressing the spontaneous regression of sequestrated intervertebral discs. We reviewed all publications with lumbar disc herniations, sequestrated subtype.

Lumbar fusion versus nonoperative management for treatment of discogenic low back pain: a systematic review and meta-analysis of randomized controlled trials.

Study Design: Systematic review and meta-analysis of randomized controlled trials (RCTs).

Objective: To evaluate the current evidence comparing lumbar fusion to nonoperative management for the treatment of chronic discogenic low back pain.

Background And Context: Discogenic low back pain is a common and sometimes disabling condition.