Publications by authors named "A Glueck"
Article Synopsis
- - Secukinumab, an anti-IL-17A monoclonal antibody, shows significant improvement in psoriasis by 12 weeks, but its long-term molecular effects on inflammation were previously unclear.
- - A 52-week study revealed that patients treated with secukinumab continued to show histological and transcriptomic improvements in psoriatic lesions, with 14 out of 24 patients achieving significant clinical response (≥ 75% improvement).
- - Analysis of skin biopsies indicated that while some genomic profiles of responders improved, they only partially overlapped at different time points; distinct transcript subsets were identified that showed unique expression patterns, suggesting mechanisms driving disease resolution.
This study examined the relationships between post-traumatic headache (PTH) and mental health symptoms after concussions to inform adolescent concussion management. Headache is the most common complaint following adolescent concussion. In this sample of 123 adolescents with concussion, there was a 5-fold increase in odds of clinically elevated anxiety, as well as increased mental health symptoms (anxiety, depression, anger, and disruptive behaviours), among adolescents with PTH relative to those without PTH.
View Article and Find Full Text PDFSeveral different types of exposure have the potential to produce olfactory and gustatory deficits related to neurotoxicity. Although the literature contains relatively few studies of such chemoreceptive dysfunction in the context of toxic exposure, this review explores the strength of such published associations. Several studies collectively demonstrated moderately strong evidence for an association between manganese dust exposure and olfactory deficits.
View Article and Find Full Text PDFObjective: Evidence of the effectiveness of virtual reality (VR) in motor and cognitive rehabilitation for traumatic brain injury (TBI) continues to be mixed. Therefore, we conducted a systematic literature review in accordance with PRISMA guidelines to strategically evaluate the strength of evidence supporting the use of VR as a rehabilitation tool for motor function and cognition in patients with TBI.
Method: The van Tulder criteria were modified to determine the quality of the outcomes of studies deemed eligible for inclusion in the review.
Background: Contemporary goals of rehabilitation after traumatic brain injury (TBI) aim to improve cognitive and motor function by applying concepts of neuroplasticity. This can be challenging to carry out in TBI patients with motor, balance, and cognitive impairments.
Objective: To determine whether use of dynamic body-weight support (DBWS) would allow safe administration of intensive motor therapy during inpatient rehabilitation and whether its use would yield greater improvement in functional recovery than standard-of-care (SOC) therapy in adults with TBI.