Publications by authors named "A Giustini"
Familial encephalopathy with neuroserpin inclusion bodies (FENIB) is a neurodegenerative pathology caused by accumulation of mutant neuroserpin (NS) polymers inside the endoplasmic reticulum (ER) of neurons, leading to cellular toxicity and neuronal death. To date, there is no cure for FENIB, and only palliative care is available for FENIB patients, underlining the urgency to develop therapeutic strategies. The purpose of this work was to create a cellular system designed for testing small molecules able to reduce the formation of NS polymers.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to evaluate whether protamine administration increases pulmonary artery pressures (PAPs) in patients undergoing specific heart surgeries, like pulmonary artery reconstruction and unifocalization.
- Conducted as a retrospective study using data from a pediatric heart center, researchers analyzed outcomes after protamine and calcium were administered, revealing significant increases in PAP at intervals post-administration.
- The findings indicated that protamine led to a notable rise in PAP after surgery, while coadministering calcium did not result in a greater increase.
We report the formulation and implementation of an extended Frenkel exciton model (EFEM) designed for simulating the dynamics of multichromophoric systems, taking into account the possible presence of interchromophore charge transfer states, as well as other states in which two chromophores are simultaneously excited. Our approach involves constructing a Hamiltonian based on calculations performed on monomers and selected dimers within the multichromophoric aggregate. Nonadiabatic molecular dynamics is addressed using a surface hopping approach, while the electronic wave functions and energies required for constructing the EFEM are computed utilizing the semiempirical floating occupation molecular orbitals-configuration interaction (FOMO-CI) electronic structure method.
View Article and Find Full Text PDFArticle Synopsis
- Direct oral anticoagulants (DOACs), such as rivaroxaban and dabigatran, are increasingly used in pediatric populations, offering benefits like reduced lab monitoring and safer profiles compared to other anticoagulants.
- The rise in DOAC usage has resulted in more pediatric patients needing perioperative care, which poses challenges due to the lack of clear management guidelines balancing thrombotic and bleeding risks.
- This review aims to educate pediatric anesthesiologists on current DOACs, their perioperative management, and potential reversal strategies, highlighting the need for more expert consensus guidelines.
Objectives: To determine if bolus administration of calcium increases pulmonary artery pressures after unifocalization procedures or pulmonary artery reconstruction surgery.
Design: Retrospective cohort study using Stanford University's data warehouse.
Setting: A large pediatric heart center within an academic quaternary care facility.