Publications by authors named "A Gimson"
Background & Aims: The National Liver Offering Scheme (NLOS) was introduced in the UK in 2018 to offer livers from deceased donors to patients on the national waiting list based, for most patients, on calculated transplant benefit. Before NLOS, livers were offered to transplant centres by geographic donor zones and, within centres, by estimated recipient need for a transplant.
Methods: UK Transplant Registry data on patient registrations and transplants were analysed to build statistical models for survival on the list (M1) and survival post-transplantation (M2).
Article Synopsis
- Changes in sleep during middle to late life are linked to an increased risk of Alzheimer's disease, highlighting the need for accurate measurement tools to study these sleep changes over time.
- A systematic review analyzed 52 studies on non-invasive sleep-measuring devices, with findings showing that devices generally overestimate total sleep time and sleep efficiency while struggling to accurately measure slow wave sleep, except for one specific headband device.
- The review emphasizes the high risk of bias in the studies due to issues like closed algorithms and incomplete data, but it identifies promising devices for future research on sleep and Alzheimer's disease risk.
Study Objectives: Sleep abnormalities emerge early in dementia and may accelerate cognitive decline. Their accurate characterization may facilitate earlier clinical identification of dementia and allow for assessment of sleep intervention efficacy. This scoping review determines how sleep is currently measured and reported in Mild Cognitive Impairment (MCI) and early dementia, as a basis for future core outcome alignment.
View Article and Find Full Text PDFBackground: Mutations in the ABCB4 gene are associated with failure of bile acid emulsification leading to cholestatic liver disease. Presentations range from progressive familial intrahepatic cholestasis type 3 (PFIC3) in childhood, to milder forms seen in adulthood.
Aims: We sought to characterize adult disease with particular reference to histology which has been hitherto poorly defined.