Publications by authors named "A Gianelli Castiglione"
Macrophages are innate immune cells present in all tissues, in which they participate in immune responses and maintenance of tissue homeostasis. They develop either from embryonic precursors or from circulating monocytes, and their functions are in part dictated by their origin. We previously observed robust monocyte recruitment and contribution to the macrophage pool in brown adipose tissue.
View Article and Find Full Text PDFPurpose: This study aimed to evaluate 1) whether having a vascular comorbidity (i.e., hypertension, hyperlipidemia, heart disease, and diabetes) was associated with self-reported issues with functional activities among persons with multiple sclerosis (MS) and 2) if certain contributing factors (i.
View Article and Find Full Text PDFThis multicentre phase II study Fondazione Italiana Linfomi (FIL)-bortezomib plus rituximab plus bendamustine (BRB) tested a combination of bendamustine (90 mg/m on days 1-2), rituximab (375 mg/m intravenously on day 1) and bortezomib (1.3 mg/m sc on days 1, 8, 15, 22) every 28 days for six cycles in 38 symptomatic patients with relapsed/refractory Waldenstrom macroglobulinaemia (RR-WM). Moreover, MYD88 and CXCR4 mutations were tested by droplet digital polymerase chain reaction (ddPCR) both at baseline and at the end of treatment in 21 patients.
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- Monocytes play a crucial role in atherosclerosis by turning into macrophages when they migrate to plaques, and this study explores how their glucose metabolism influences their behavior and contribution to the disease.
- Researchers found that higher serum glucose levels are linked to increased monocyte numbers, while restricted diets hinder monocytes from switching energy sources, which reduces their presence in the blood.
- The study highlights that glucose metabolism is vital for maintaining specific monocyte characteristics and functions, but inhibiting glucose uptake alone doesn't prevent atherosclerosis, likely because the remaining monocytes become more migratory.
Article Synopsis
- ECP is a promising treatment for managing acute rejection in heart transplant patients by modulating the immune system, particularly through the action of regulatory T cells (Treg).
- The study involved 14 heart transplant participants undergoing ECP therapy, assessing the effects on Treg frequency and their suppressive functions over time, alongside a control group.
- Results indicate that ECP significantly boosts the number and function of suppressive Tregs, particularly those marked by the transcription factor FoxP3, which helps control immune responses and prevent graft rejection.