Publications by authors named "A Ghoshal"
Malaria remains a serious global health challenge, yet treatment and control programs are threatened by drug resistance. Dihydroorotate dehydrogenase (DHODH) was clinically validated as a target for treatment and prevention of malaria through human studies with DSM265, but currently no drugs against this target are in clinical use. We used structure-based computational tools including free energy perturbation (FEP+) to discover highly ligand efficient, potent, and selective pyrazole-based DHODH inhibitors through a scaffold hop from a pyrrole-based series.
View Article and Find Full Text PDFObjectives: In this study, our primary objectives were to validate the palliative prognostic index (PPI) tool in the context of palliative care for patients with advanced cancer. Specifically, we aimed to assess the accuracy of the PPI in predicting actual survival in these patients through prospective validation.
Materials And Methods: To achieve our objectives, we enrolled a cohort of 227 advanced cancer patients receiving palliative care.
RA-0003022 () was identified as a high-quality covalent chemical probe for nsP2 cysteine protease (nsP2pro). Isoxazole covalently captured the active site C478 and inactivated the enzyme with a / ratio of 6000 Ms. A negative control analog RA-0025453 () retained the covalent warhead but demonstrated >100-fold decrease in enzyme inhibition.
View Article and Find Full Text PDFArticle Synopsis
- Chikungunya virus (CHIKV) is a mosquito-borne virus causing major outbreaks, with no FDA-approved treatments available.
- Researchers optimized a screening assay for CHIKV's essential protein nsP2 and identified 153 potential drug candidates, including RA-0002034.
- RA-0002034 effectively inhibits CHIKV nsP2 activity and viral replication, making it a promising compound for future therapeutic development against CHIKV and similar viruses.
Background: Estimating prognosis can be a barrier to timely palliative care involvement. The modified Hospitalized-patient One-year Mortality Risk (mHOMR) score uses hospital admission data to calculate the risk of death within 12 months and may be a useful tool to trigger a referral to palliative care.
Methods: The mHOMR tool was retrospectively applied to consecutive acute admissions to a quaternary cancer center in Toronto, Canada from March 1 to May 31, 2018.