Publications by authors named "A Ghazi"

To develop and validate a high-fidelity, nonbiohazardous simulator model for the ultrasound-guided percutaneous nephrolithotomy procedure. We employed a systematic framework based on Delphi consensus and modern education theory to design a simulation model. Twelve expert surgeons provided input through a hierarchal task analysis and identified procedural tasks, anatomical landmarks, and potential errors.

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Introduction: With the advancement of surgical technology, the opportunity to integrate novel surgical preparation is imperative to improve patient outcomes and enhance safety.

Methods: Patient specific perfused kidney phantoms including the tumor, parenchyma, artery, vein, and calyx were fabricated using 3D-printing and hydrogel injection molding from scans of 25 patients scheduled for robotic partial-nephrectomy (RAPN). Models are validated for anatomical accuracy, mechanical, functional properties and surrounded by the other models of relevant anatomy in a body cast for a simulated surgical rehearsal.

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Article Synopsis
  • * The survey had a 28.6% completion rate with 201 responses, revealing that while about half of the institutions using SP platforms have done so for over 2 years, structured training is limited, leading to concerns about hands-on experience and the learning curve associated with SP procedures.
  • * Despite recognizing the clinical benefits of SP surgery, many trainees do not view proficiency in it as essential for career advancement; however, predictors of future SP implementation include academic aspirations and the availability of SP platforms
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  • Reproductive status significantly affects metabolism and health throughout an organism's lifespan, with mitochondrial function being a key mediator in this relationship.
  • Research using a germline ablation model showed that loss of germline stem cells (GSC) decreases mitochondrial volume and respiratory function in young adults, yet helps preserve mitochondrial activity as organisms age and when facing cold stress, leading to better survival rates.
  • The study identified that the transcription factor NHR-49/PPARα is crucial for maintaining mitochondrial health and cold stress resistance, highlighting the complex interplay between reproductive signals and overall health.
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