Publications by authors named "A Ghanbari"
The study aimed to understand the impact of the sonic-hedge signal pathway (SHH) on mouse neural stem cells. We manipulated the pathway using purmorphamine (Pur) and Gant 61 and observed the effects on cell viability, neurosphere formation, and gene expression. We found that activating the SHH pathway with Pur increased cell viability, neurosphere formation, and the expression of specific genes, promoting the differentiation of neural stem cells into mature cells.
View Article and Find Full Text PDFBackground: There is a standard methodology for measuring and evaluating the availability and affordability of selected medicines in the healthcare system, especially in low- and middle-income countries.
Aim: To investigate availability, affordability and accessibility of medicines in the Islamic Republic of Iran in 2021 and compare the results with those from 2019.
Methods: This descriptive cross-sectional study investigated the availability and affordability of 60 selected medicines in Islamic Republic of Iran.
Cellular senescence is a permanent state of cell cycle arrest that occurs in proliferating cells under various stresses causing age-related disorders. This study investigated the role of D-galactose in inducing premature senescence of neural stem cells (NSCs) and the genes involved in this process. After NSC isolation and proliferation, senescence was induced with 10, 20, or 30 µM concentrations of D-galactose for 24 h.
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- Carpal tunnel syndrome (CTS) is a prevalent issue resulting from median nerve pressure, impacting 1% to 5% of individuals, and various treatment options exist, including medications, rest, splints, and therapies like ultrasound and nerve-gliding exercises.
- This study aimed to evaluate how effective ultrasound therapy is compared to nerve-gliding exercises in alleviating symptoms, enhancing hand functionality, and improving electrodiagnostic results for those with CTS.
- Results showed that both treatments significantly improved symptom severity and function, but ultrasound therapy had a notable impact on reducing nerve latency and pain, indicating both methods are beneficial in the short term.
Olfactory dysfunction (OD) is a non-motor symptom of Parkinson's Disease, affecting 75-95% of the patients. This symptom usually emerges before the clinical diagnosis, and patients with OD present with more severe forms of PD and need higher doses of therapy. It remains unknown whether OD is just a mere non-motor symptom or if it is a part of a series of pathological changes in different brain regions of the affected patients.
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