WDR26 depletion alters chromatin accessibility and gene expression profiles in mammalian cells.

WD-repeat containing protein 26 (WDR26) is an essential component of the CTLH E3 ligase complex. Mutations in WDR26 lead to Skraban-Deardorff, an intellectual disability syndrome with clinical features resembling other disorders arising from defects in transcriptional regulation and chromatin structure. However, the role of WDR26 and its associated CTLH complex in regulating chromatin or transcription has not been elucidated.

Health promotion campaigns using social media: association rules mining and co-occurrence network analysis of Twitter hashtags.

Background: Social media hashtags play a significant role in increasing the visibility of health information by making it easier for people to explore health-related content. Health promotion campaigns use campaign-specific hashtags to disseminate health-related messages, enabling individuals to access accurate and timely resources and updates. The study aims to discover patterns of connection between hashtags and identify the most influential hashtags used on Twitter in the American Heart Month campaigns.

Interferon Point Alteration in Hospitalized Patients with and Without COVID-19.

Introduction: Integrating traditional Chinese medicine with Western medicine has been extensively studied in managing respiratory disease. Therefore, in this study, we aimed to examine interferon point alteration (IPA) and its association with disease severity in patients with COVID-19.

Methods: This cross-sectional study was conducted on patients hospitalized due to COVID-19 with lung involvement.

Significant Pathologic Response Following Neoadjuvant Therapy and Curative Resection in Patients With Rectal Cancer: Surgical and Oncological Outcomes From a Retrospective Cohort Study.

Aim: This study evaluated surgical complication rates, recurrence-free survival, overall survival (OS), and stoma status of patients with rectal cancer after significant pathologic response following neoadjuvant treatment and curative resection. Pathologic complete response (pCR) and near-pCR patients constitute patients in our study.

Methods: Included was a retrospective cohort study of patients with rectal cancer who were diagnosed between July 2011 and September 2022 and who underwent neoadjuvant therapy and surgical resection.