Publications by authors named "A Ghaderi"
Background: To overcome the limitations of IL-15 and to improve the efficacy of IL-15 in immunotherapy, several strategies have been introduced.
Objective: The objective of this study was to generate and evaluate a novel anti-CD8/IL-15 (N72D)/Sushi fusion protein with the potential to target CD8 T cells and enhance functionality of CD8 T cells against tumor cells.
Methods: In this connection, a novel fusokine that contains IL-15(N72D), a Sushi domain, and anti-CD8 single-chain fragment variable (scFv) was designed.
Background/objectives: Nurse-like cells (NLCs) derived from monocytes in the tumor microenvironment support the growth of chronic lymphocytic leukemia (CLL) cells. Here, we investigated the effects of a CX3CR1 (fractalkine receptor) antagonist (KAND567) on autologous monocytes and their pro-survival effects on CLL cells in vitro.
Methods: Plasma concentration of CX3CL1 was determined by ELISA and CX3CR1 expression by flow cytometry.
Background: Oral Squamous Cell Carcinoma (OSCC) is a pressing global health challenge. Long non-coding RNAs (lncRNAs) have emerged as pivotal regulators. Among these, the lncRNA ANRIL (antisense non-coding RNA in the INK4 locus) has a role in cancer progression.
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- GABA receptors are linked to drug addiction, sleep issues, and aging, but their interrelationships are not well researched; this study focuses on how blocking these receptors influences methamphetamine (METH) reward memory in sleep-deprived rats.
- Adult and adolescent male Wistar rats underwent seven days of rapid-eye movement sleep deprivation and then were conditioned with METH before testing their memory retrieval after administering the GABA receptor agonist baclofen.
- Baclofen reduced METH reward memory retrieval in both age groups, with stronger effects seen in adolescents, and the high dose lowered GABA overexpression in adolescent rats, suggesting age and sleep deprivation play significant roles in addiction mechanisms.