From 1977 to 1982, the authors attempted a malaria suppression trial in North Mara District, Tanzania, to see whether the incidence of Burkitt's lymphoma (BL) could be lowered by reducing the level of malarial infection in a child population below 10 years of age. Immediately after initiation of the suppression trial, the prevalence of malaria fell drastically in the Mara children; however, soon after, the rate of malarial infection rose again in the trial area in spite of continued chloroquine distribution, and by 1981 the prevalence of malarial infection again reached the high levels that had prevailed in the North Mara lowlands before 1977. However, during the period of chloroquine distribution in North Mara, the level of malarial infection there was constantly lower than that observed in a comparison area in South Mara, although the two areas had been similar with respect to malaria endemicity prior to the intervention.
View Article and Find Full Text PDFSerial in vitro and in vivo tests for chloroquine sensitivity of Plasmodium falciparum were carried out from 1979 to 1982 in an area of E. Africa where chemosuppression with chloroquine had been attempted since 1977. Within 1(1/2) years there were signs of a decreasing drug response.
View Article and Find Full Text PDFThirty-four males and 45 females who participated in household surveys 15 or 25 years earlier in rural Denmark were interviewed in 1982 about present and past food habits. Comparison of the information from the survey and the two interviews indicates that recall of past diet is strongly influenced by present dietary habits. As the relative classification of individuals according to their food habits appears to have changed little over time, information on current diet, perhaps supplemented by information on particular changes, can provide useful classification of individuals for epidemiologic purposes.
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