Publications by authors named "A Gerbes"
Article Synopsis
- Bacterial infections are a major issue for patients with cirrhosis, impacting their overall health due to their role in increasing morbidity and mortality.
- This study investigates the role of cytosolic phospholipase A2 (cPLA2) in the activation of human Kupffer cells (HKCs) by gram-negative bacteria, specifically looking at how E. coli influences HKC activation through specific signaling pathways.
- The findings suggest that cPLA2 is crucial for HKC activation in response to E. coli, linking its activity to the regulation by transcription factors STAT3 and RelB via the ERK and non-canonical NF-κB signaling pathways, potentially paving the way for therapeutic strategies in managing bacterial infections in cirrhotic patients
The progression of cirrhosis with clinically significant portal hypertension towards decompensated cirrhosis remains clinically challenging and the evolution towards acute-on-chronic liver failure (ACLF), with one or more extrahepatic organ failures, is associated with very high mortality. In the last decade, significant progress has been made in the understanding of the mechanisms leading to decompensation and ACLF. As portal hypertension advances, bacterial translocation across an impaired gut barrier culminates in endotoxaemia, systemic inflammation and cirrhosis-associated immune dysfunction (CAID).
View Article and Find Full Text PDFBackground: The administration of an appropriate empirical antibiotic treatment is essential in cirrhosis and severe bacterial infections. We aimed to investigate the predictors of clinical response of empirical antibiotic treatment in a prospective cohort of patients with cirrhosis and bacterial and fungal infections included in the International Club of Ascites "Global Study."
Methods: Patients hospitalized with cirrhosis and bacterial/fungal infection were prospectively enrolled at 46 centers.
Background: The number of complications in patients admitted for cirrhosis has increased over time. Portal hypertension is the driver of many complications of cirrhosis. TIPS placement is the most effective treatment of portal hypertension.
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