The human VGLUT3-pT8I mutation elicits uneven striatal DA signaling, food or drug maladaptive consumption in male mice.

Cholinergic striatal interneurons (ChIs) express the vesicular glutamate transporter 3 (VGLUT3) which allows them to regulate the striatal network with glutamate and acetylcholine (ACh). In addition, VGLUT3-dependent glutamate increases ACh vesicular stores through vesicular synergy. A missense polymorphism, VGLUT3-p.

Time trends in infectious and chronic disease consultations in Dakar, Senegal: Impact of COVID-19 sanitary measures.

Background: The impact of COVID-19 sanitary measures on the time trends in infectious and chronic disease consultations in Sub-Saharan Africa remains unknown.

Methods: We conducted a cohort study on all emergency medical consultations from January 2016 to July 2020, from SOS Medecins in Dakar, Senegal. The consultation records provided basic demographic information such as age, ethnicity (Senegalese or Caucasian), and sex as well as the principal diagnosis using an ICD-10 classification ("infectious", "chronic", and "other").

[From the Antonine Plague to the Cyprian Plague: Scopes and consequences of global plagues in the Roman Empire in the 3rd century AD.].

Between the 2nd and 3rd centuries the Roman Empire suffered two great plagues, the Antonine Plague, of which there is a bibliography, and the lesser known Plague of Cyprian. As an overview, both pandemics resemble the crisis that in 2020 the Coronavirus is generating in many aspects of human life. This article focuses on the impact that the Cyprian plague had in the context of the crisis of the third century, its mortality is estimated between 10-20% of the population in the affected places, finally its effects generated several of the necessary conditions for the transition from the ancient to the medieval world.