Publications by authors named "A Gelfand"
Objective: The purpose of the study was to examine the association between short-acting beta agonist (SABA), antibiotic and oral corticosteroid (OCS) use and mortality and cardiopulmonary outcomes in chronic obstructive pulmonary disease (COPD).
Design: Retrospective cohort study using administrative health data from 1 April 2011 to 31 March 2020.
Setting: Alberta, Canada.
Background: New daily persistent headache (NDPH) is a challenging and understudied primary headache disorder with no known effective treatment. Although the International Classification of Headache Disorders criteria require that the new onset continuous headache be present for at least three months before diagnosing NDPH, the biologic basis for when a new, continuous headache starts to behave as NDPH is unknown, and some pediatric headache experts consider that the minimum duration criterion could be shorter.
Methods: In this retrospective study, we reviewed the intake questionnaires and medical records of 5-17 year-olds seen in neurology clinic for headache at the Children's Hospital of Philadelphia.
Objectives: The objective of this study is to determine the time to ventilator liberation and decannulation after tracheostomy placement in children with bronchopulmonary dysplasia (BPD) and pulmonary hypertension.
Methods: A prospective cohort study included all children (<18 years old) who underwent tracheostomy between 2015 and 2021 with or without a diagnosis of BPD. The primary outcomes were time to ventilator liberation, tracheostomy decannulation, or death with tracheostomy in place.
Article Synopsis
- In T-cell acute lymphoblastic leukemia (T-ALL), over half of the cases show abnormal activation of Notch1, which triggers cancer development.
- A specific Cannabis strain was found to cause cancer cell death by blocking the maturation of Notch1, and this study identified three cannabinoids (CBD, CBDV, and a new one named 331-18A) that work together to mimic this effect.
- These cannabinoids activate specific receptors to induce a stress response that prevents Notch1 maturation, leading to reduced cancer cell viability, decreased tumor size in mouse models, and potential new therapy options for treating T-ALL and similar cancers.
Objective: To identify and disseminate research priorities for the headache field that should be areas of research focus during the next 10 years.
Background: Establishing research priorities helps focus and synergize the work of headache investigators, allowing them to reach the most important research goals more efficiently and completely.
Methods: The Headache Research Priorities organizing and executive committees and working group chairs led a multistakeholder and international group of experts to develop headache research priorities.