Publications by authors named "A Geeraerts"
Article Synopsis
- Real-time symptom reporting during reflux monitoring is important for evaluating esophageal symptoms, but the psychological and physiological factors involved are not well understood.
- A study was conducted with adult patients using questionnaires and pH-impedance monitoring to analyze how these factors influence symptom reporting.
- Results showed that psychological factors like anxiety and physiological factors such as reflux episodes affect symptom frequency, but machine learning models struggled to accurately classify symptom associations, indicating complexity in understanding reflux symptoms.
Background & Aims: Physiological and psychological factors have been found to influence esophageal symptom reporting. We aimed to evaluate which of these factors are associated with 3 reflux symptom severity outcomes (ie, Total Reflux, Heartburn, and Sleep Disturbance) through a traditional statistical and a complementary machine-learning approach.
Methods: Consecutive adult patients with refractory heartburn/regurgitation symptoms underwent standard 24-hour pH-impedance monitoring and completed questionnaires assessing past and current gastrointestinal and psychological health.
Objective: Historically, psychological processes are associated with disorders at the functional end of the gastro-oesophageal reflux disease (GERD) spectrum. However, recent research suggests that psychological symptoms are relevant across the GERD spectrum. We aim to investigate whether psychological symptoms are associated with reflux phenotype (True GERD, Borderline GERD, reflux hypersensitivity, functional heartburn) along the GERD spectrum in a cohort of refractory reflux patients.
View Article and Find Full Text PDFBackground: The Chicago classification primarily utilizes ten 5 mL liquid swallows in a supine position as the standard high-resolution esophageal manometry (HRM) protocol. HRM can be performed with varying volumes and consistencies and in an upright position. We aimed to determine the impact on HRM results by (1) position, (2) swallows of differing volume and consistency, and (3) perception of bolus passage.
View Article and Find Full Text PDFBackground: Proton pump inhibitors (PPI) have no effect on non-acid reflux events which can continue to provoke gastro-oesophageal reflux disease (GERD) symptoms. Baclofen, a γ-aminobutyric acid agonist, can decrease non-acid reflux but its symptomatic benefit in refractory GERD symptoms is understudied.
Aims: To assess the efficacy of baclofen 10 mg t.