[Surveillance of falciparum malaria susceptibility to antimalarial drugs and policy change in the Comoros].

Between May and June 2001, efficacy of chloroquine was assessed in 5 sentinel sites in the 3 Comoro islands. Among the 183 children, age range between 6 and 59 months, followed up for 14 days, clinical failure rates ranged between 31.2 and 73.

[Diluted injectable quinine in the intramuscular and intrarectal route: comparative efficacity and tolerance in malaria treatment for children ].

The intramuscular (i.m.) route is generally used for treatment of childhood falciparum malaria in outlying health care units in Togo.

[Treatment of cerebral malaria in African children by intravenous quinine: comparison of a loading dose regimen to a regimen without a loading dose].

Objective: To compare in a randomized study the efficacy and the toxicity of the new WHO intravenous quinine treatment of cerebral malaria including a loading dose regimen to a regimen without loading dose.

Patients And Methods: Seventy-two children eight months to 15 years of age with cerebral malaria were included. Quinine formiate was administered to a group of 35 patients in an initial loading dose of 20 mg salt/kg (equivalent to 17.

[Severe malaria in children in Togo].

Background: The definition of severe malaria is no longer limited to cerebral malaria, but is as well extended to other clinical forms of the disease. This work analyses epidemiological, clinical and evolutive aspects of severe malaria in Togo.

Patients And Methods: This study included 549 children, aged from 0 to 15 years, hospitalized in 1994-5 in the pediatric department of the Lome-Tokoin University Teaching Hospital for severe malaria as defined by World Health Organization (WHO) criteria.

[Current aspects of malarial chemoresistance of subjects autochthonous in the OCCGE countries (West Africa)].

Within the context of the monitoring of malaria drug resistance in the countries of the OCCGE, a workshop has been organized in order to sum up the surveys carried out by the national teams. For active or passive monitoring mainly the in vivo tests have been used. The native population, mainly school children, was studied.