Publications by authors named "A Gautier"
Bitter is one of the five basic taste qualities, along with salty, sour, sweet and umami, used by mammals to access the quality of their food and orient their eating behaviour. Bitter taste detection prevents the ingestion of food potentially contaminated by bitter-tasting toxins. Bitter taste perception is mediated by a family of G protein-coupled receptors (GPCRs) called TAS2Rs.
View Article and Find Full Text PDFAim: To develop processes for the development of decentralised clinical trial methodology for Aotearoa New Zealand, focussing on equity of access to cancer clinical trials for Māori, Pacific people, vulnerable communities and those in rural settings.
Methods: A national steering committee supported by Te Aho o Te Kahu - Cancer Control Agency was formed to: guide the adaptation and implementation of overseas decentralised clinical trial models to suit the needs of Aotearoa New Zealand with an equity focus; provide high-level oversight and expertise for direction and development of policies, procedures and infrastructure compliant with ICH GCP R2; and implement a national strategy.
Results: Twelve standard operating procedures were developed, as well as a supervision plan and a glossary.
Article Synopsis
- - Membrane contact sites (MCSs) help organelles coordinate activities, but their small size and dynamic nature make them hard to study with traditional imaging methods.
- - Researchers developed chemogenetic reporters that enhance the imaging of MCSs in both lab and living systems, enabling the exploration of complex biological questions.
- - They introduced a new biosensor, PRINCESS, which can detect MCSs and measure calcium dynamics simultaneously, revealing a mechanism where calcium signaling affects the positioning of the endoplasmic reticulum and mitochondria.
Article Synopsis
- - Metabolic dysfunction-associated steatotic liver disease (MASLD) is prevalent among obese individuals and shows differences between sexes. A study sought to create a noninvasive blood test using mid-infrared (MIR) metabolic fingerprinting to diagnose metabolic dysfunction-associated steatohepatitis (MASH) in those with severe obesity.
- - The study involved 382 patients undergoing bariatric surgery, with liver biopsies assessed to establish a scoring algorithm based on MIR spectroscopy. In women, MASH was diagnosed in 14.3% of cases, showing high sensitivity (86%) and specificity (81%) for correctly identifying the condition.
- - For men, the test's performance was notably less effective, with a MASH diagnosis
Article Synopsis
- The study investigates the effectiveness and safety of using a 3D computational model fused with real-time fluoroscopy to guide left atrial appendage closure (LAAC) for patients with non-valvular atrial fibrillation.
- The research included 106 patients who underwent the procedure, achieving a 100% success rate for device implantation and meeting primary efficacy criteria in 89% of cases.
- The approach was deemed safe, with only 1.9% of patients experiencing major complications, suggesting that this technique could enhance LAAC outcomes.