Publications by authors named "A Gateva"
Aim: To evaluate the relationship between common carotid artery intima media thickness (CIMT) in patients with prediabetes and new-onset diabetes mellitus without proven cardiovascular disease and some classic cardio-metabolic risk factors.
Patients And Methods: The study included 461 obese patients with an average age of 53.2 ± 10.
Article Synopsis
- This study investigates the role of the adipokine meteorin-like protein (Metrnl) and the protein zonulin in women with polycystic ovary syndrome (PCOS), focusing on their relationship with obesity, hormonal levels, and metabolic health.
- A total of 58 women with PCOS and 30 controls were assessed, measuring hormone levels and metabolic parameters using blood tests and other evaluations, but no significant differences in Metrnl and zonulin levels were found between the two groups.
- Overweight and obese participants had higher Metrnl levels compared to normal-weight individuals, particularly in those with abdominal obesity and insulin resistance, highlighting the complex interplay between these factors in PCOS
Despite the beneficial effect of myo-inositol on metabolic, hormonal, and reproductive parameters of polycystic ovary syndrome (PCOS) patients, 28% to 38% could be resistant to this treatment. The combination with the milk protein α-lactalbumin can be a useful therapeutic approach to overcome inositol resistance and achieve ovulation in these women. This open-label prospective study aimed to compare the effects of supplementing myo-inositol plus α-lactalbumin vs myo-inositol alone on reproductive and metabolic abnormalities in PCOS.
View Article and Find Full Text PDFBackground: Obesity and diabetes are related to chronic low-grade inflammation. As a pro-inflammatory cytokine, IL-18 stimulates various cell types and has pleiotropic functions.
Objective: To assess the levels of IL-18 in subjects from the entire spectrum of glycemic disorders.
Background: Fibroblast growth factor 21 is a peptide primarily secreted by the liver in response to peroxisome proliferator-activated receptor-α activation which plays an important role in regulating carbohydrate and lipid metabolism. This study investigated the association between fibroblast growth factor 21 and prediabetes in obese patients with non-alcoholic fatty liver disease in adult population.
Methods: A total of 85 obese non-alcoholic fatty liver disease patients without (n = 49) and with prediabetes (n = 36) were included.