Antigen affinity and site of immunization dictate B cell recall responses.

Protective antibodies against HIV-1 require unusually high levels of somatic mutations introduced in germinal centers (GCs). To achieve this, a sequential vaccination approach was proposed. Using HIV-1 antibody knockin mice with fate-mapping genes, we examined if antigen affinity affects the outcome of B cell recall responses.

Transcriptome Analysis Identifies Accumulation of Natural Killer Cells with Enhanced Lymphotoxin-β Expression during Glioblastoma Progression.

Glioblastomas are the most common primary brain tumors. Despite extensive clinical and molecular insights into these tumors, the prognosis remains dismal. While targeted immunotherapies have shown remarkable success across different non-brain tumor entities, they failed to show efficacy in glioblastomas.

Traveling surface waves of moderate amplitude in shallow water.

We study traveling wave solutions of an equation for surface waves of moderate amplitude arising as a shallow water approximation of the Euler equations for inviscid, incompressible and homogeneous fluids. We obtain solitary waves of elevation and depression, including a family of solitary waves with compact support, where the amplitude may increase or decrease with respect to the wave speed. Our approach is based on techniques from dynamical systems and relies on a reformulation of the evolution equation as an autonomous Hamiltonian system which facilitates an explicit expression for bounded orbits in the phase plane to establish existence of the corresponding periodic and solitary traveling wave solutions.