Publications by authors named "A Gastebois"
Mycopathologia
February 2024
Article Synopsis
- * Treatment can be difficult due to limited available drugs and the presence of multiresistant microorganisms, emphasizing the need for better understanding of environmental contamination sources.
- * Occupational exposure to fungi-rich environments, such as compost and agricultural fields, should be avoided for cystic fibrosis patients, along with regular indoor microbiological monitoring to reduce mold exposure.
J Fungi (Basel)
January 2023
Article Synopsis
- The study focuses on a pathogenic fungus and investigates its survival mechanisms, specifically the role of a transcription factor called PIG1 in the production of dihydroxynaphtalene (DHN)-melanin.
- By using CRISPR-Cas9 to create deletion mutants, researchers found that the absence of PIG1 hindered melanin production, resulting in a thinner and disorganized cell wall that decreased the fungus's ability to survive environmental stressors.
- The research highlights that PIG1 not only aids in melanin biosynthesis but may also play a crucial role in the fungus's overall virulence by helping it evade the host immune response.
Mycopathologia
December 2021
Article Synopsis
- The genus Scedosporium includes at least ten species, four of which can infect the lungs of cystic fibrosis patients.
- Scedosporium dehoogii is commonly found in soil but has not been linked to human lung infections.
- The first genome sequence of S. dehoogii has been reported, providing important insights into the genetic factors related to disease in the Scedosporium genus.
J Fungi (Basel)
July 2021
Article Synopsis
- Fungal pathogens are prevalent in cystic fibrosis patients and must overcome the immune response, particularly the reactive oxygen species (ROS) produced by immune cells.
- These pathogens develop antioxidant systems, including superoxide dismutases (SODs), which help protect against oxidative stress and contribute to their survival in the host.
- A specific SOD mutant showed increased susceptibility to oxidants and antifungals, and its absence led to more efficient killing by immune cells, highlighting its potential role in evading host defenses and possibly influencing cell wall structure.
