Biomedical Application Prospects of Gadolinium Oxide Nanoparticles for Regenerative Medicine.

Background/objectives: The aim was to study the possibilities of biomedical application of gadolinium oxide nanoparticles (GdO NPs) synthesized under industrial conditions, and evaluate their physicochemical properties, redox activity, biological activity, and safety using different human cell lines.

Methods: The powder of GdO NPs was obtained by a process of thermal decomposition of gadolinium carbonate precipitated from nitrate solution, and was studied using transmission electron microscopy (TEM), X-ray diffraction (XRD), Raman spectroscopy, mass spectrometry, and scanning electron microscopy (SEM) with energy dispersive X-ray analyzer (EDX). The redox activity of different concentrations of GdO NPs was studied by the optical spectroscopy (OS) method in the photochemical degradation process of methylene blue dye upon irradiation with an optical source.

Development of Technology for the Synthesis of Nanocrystalline Cerium Oxide Under Production Conditions with the Best Regenerative Activity and Biocompatibility for Further Creation of Wound-Healing Agents.

The issue of effective wound healing remains highly relevant. The objective of the study is to develop an optimal method for the synthesis of nanosized cerium oxide powder obtained via the thermal decomposition of cerium carbonate precipitated from aqueous nitrate solution for the technical creation of new drugs in production conditions; the select modification of synthesis under different conditions based on the evaluation of the physicochemical characteristics of the obtained material and its biological activity, and an evaluation of the broad-spectrum effect on cells involved in the regeneration of skin structure as well as antimicrobial properties. Several modes of the industrial synthesis of cerium dioxide nanoparticles (NPs) were carried out.

[Endoscopic vacuum therapy in minimally invasive treatment of esophageal perforations].

Objective: To compare the results of endoscopic vacuum therapy (EVT) and open surgery for esophageal perforations.

Material And Methods: The study included 60 patients with esophageal perforations between 2010 and 2022. The main group included 29 patients who underwent minimally invasive treatment with EVT, the control group - 31 patients after open surgical interventions.

[Endoscopic treatment of bronchial complications after lung transplantation].

Objective: To analyze the incidence and structure of bronchial complications following lung transplantation and evaluate an effectiveness of endoscopic treatment of these events.

Material And Methods: The study enrolled 50 patients after bilateral lung transplantation (24 men and 26 women). Mean age of patients was 35.

Indium iodide single crystal: breakthrough material for infrared acousto-optics.

Measurements of the refractive indices and the full set of longitudinal acousto-optical figures of merit in an orthorhombic single-crystal indium iodide (InI) were carried out. The high acousto-optic characteristics ( up to 1100×10) and strong optical anisotropy (=0.47) make it possible to design various types of high-performance acousto-optic devices of the middle and far-infrared spectral range.