Publications by authors named "A Garcia-Montero"
Article Synopsis
- Systemic mastocytosis (SM) is a complex disease linked to abnormal mast cells that release mediators affecting the immune environment.
- The study aimed to explore the blood profiles of B-cells, plasma cells, and antibody types in 108 SM patients compared to healthy individuals.
- Results showed increased immature B-cells and elevated IgM and IgD levels in SM patients, alongside decreased plasma cells across various IgH types, with unique immune patterns based on the SM subtype.
Background: The increase in life expectancy and long-lived individuals is a challenge for public health and provides an opportunity to understand the determinants of longevity. However, few studies have addressed the factors associated with the health status and quality of life in a long-lived individual population. We described the perceived health, clinical status, quality of life, and dependency for activities of daily living in a representative population in Castile and Leon, Spain.
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- Systemic mastocytosis (SM) is a complex disease marked by an increase in abnormal mast cells that can affect the immune system and tumor environment.
- Researchers analyzed blood samples from 115 SM patients and 83 healthy individuals to assess the distribution of various immune cells and their relationship with disease characteristics.
- Findings indicated that SM patients had reduced levels of specific immune cell types compared to healthy controls, with these variations depending on the subtype of SM and certain genetic factors linked to the disease.
Article Synopsis
- The study explores the connection between hereditary alpha-tryptasemia (HAT) and mast cell (MC) disorders, aiming to understand how common HAT is among healthy individuals and patients with different types of MC activation syndromes and mastocytosis.
- The research involved 959 participants, where HAT was found in 4% of healthy donors and higher rates in non-clonal MCAS (29%) and mastocytosis (18%) patients, with more HAT cases in certain mastocytosis subtypes.
- Findings indicate that while HAT is associated with higher serum baseline tryptase levels and a greater occurrence of anaphylaxis in general, it does not necessarily elevate the risk of anaphylaxis severity in
Bone and Cytokine Markers Associated With Bone Disease in Systemic Mastocytosis.
J Allergy Clin Immunol Pract
May 2023
Background: Mastocytosis encompasses a heterogeneous group of diseases characterized by tissue accumulation of clonal mast cells, which frequently includes bone involvement. Several cytokines have been shown to play a role in the pathogenesis of bone mass loss in systemic mastocytosis (SM), but their role in SM-associated osteosclerosis remains unknown.
Objective: To investigate the potential association between cytokine and bone remodeling markers with bone disease in SM, aiming at identifying biomarker profiles associated with bone loss and/or osteosclerosis.