Publications by authors named "A Garcia-Molina"
Article Synopsis
- - Participants in the MindFit Project, a study involving chronic stroke survivors, engaged in different intervention groups, including mindfulness-based stress reduction and physical exercise, to address their numerous physical, cognitive, and emotional challenges post-stroke.
- - A qualitative study involving interviews with participants revealed that they found the interventions generally beneficial, with mindfulness helping emotional regulation, physical exercise boosting capabilities, and cognitive training aiding mental functions; the group environment provided peer support despite some challenges related to participant diversity.
- - The findings underscore the complexity of stroke recovery and advocate for holistic, patient-centered rehabilitation strategies that integrate both physical and cognitive approaches, with remote delivery being a practical yet challenging option for survivors.
Living organisms have developed finely regulated homeostatic networks to mitigate the effects of environmental fluctuations in transition metal micronutrients, including iron, zinc, and copper. In Saccharomyces cerevisiae, the tandem zinc-finger protein Cth2 post-transcriptionally regulates gene expression under conditions of iron deficiency by controlling the levels of mRNAs that code for non-essential ferroproteins. The molecular mechanism involves Cth2 binding to AU-rich elements present in the 3' untranslated region of target mRNAs, negatively affecting their stability and translation.
View Article and Find Full Text PDFAllosteric modulators of the metabotropic group II receptors, mGluR and mGluR, have been widely explored due to their ability to modulate cognitive and neurological functions in mood disorders, although none have been approved yet. In our search for new and selective mGluR negative allosteric modulators (NAMs), series of 6,7-dihydropyrazolo[1,5-]pyrazin-4(5)-one derivatives were identified from our published series of 1,3,5-trisubstituted pyrazoles. SAR evolution of the initial hit resulted in 100-fold improvement in the mGluR NAM potency and subsequent selection of compound based on its overall profile, including selectivity and ADMET properties.
View Article and Find Full Text PDFIntroduction: The first targeted therapy in oncology, imatinib, revolutionized chronic myeloid leukemia (CML) treatment and spurred research in targeted therapies for various cancers. CML results from a chromosomal translocation, forming the BCR-ABL1 fusion gene. Asciminib has been recently approved for 3rd-line refractory or intolerant patients.
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