Publications by authors named "A Garcia-Jaraquemada"
The lack of knowledge regarding the pathogenesis of IBD is a challenge for the development of more effective and safer therapies. Although in vivo preclinical approaches are critical for drug testing, none of the existing models accurately reproduce human IBD. Factors that influence the intra-individual response to drugs have barely been described.
View Article and Find Full Text PDFMacroH2A histone variants have a function in gene regulation that is poorly understood at the molecular level. We report that macroH2A1.2 and macroH2A2 modulate the transcriptional ground state of cancer cells and how they respond to inflammatory cytokines.
View Article and Find Full Text PDFTranscriptomic identification of TMIGD1 and its relationship with the ileal epithelial cell differentiation in Crohn's disease.
Am J Physiol Gastrointest Liver Physiol
August 2020
Article Synopsis
- Crohn's disease (CD) is a complex illness with many unknowns regarding its underlying biological mechanisms; a study aimed to investigate the gene expressions in ileum tissues from CD patients and controls.
- Analysis revealed that the TMIGD1 gene is underexpressed in CD-affected tissues, particularly in inflamed ileum, suggesting a potential link to the disease's pathology.
- Using advanced transcriptomic techniques, the research identifies TMIGD1 as a new target for understanding CD, connecting it to processes of cell recovery and tissue remodeling that could inform future therapies.
Background And Aims: Steroid-refractoriness is a common and unpredictable phenomenon in ulcerative colitis [UC], but there are no conclusive studies on the molecular functions involved. We aimed to assess the mechanism of action related to steroid failure by integrating transcriptomic data from UC patients, and updated molecular data on UC and glucocorticoids.
Methods: MicroRNA [miRNA] and mRNA expression were evaluated by sequencing and microarrays, respectively, from rectal biopsies of patients with moderately-to-severe active UC, obtained before and on the third day of steroid treatment.
Article Synopsis
- * The study investigates the effects of interleukin-10 (IL-10) on improving the response to glucocorticoids by enhancing the intestinal barrier in lab models and identifies key molecular processes involved, including the role of p38 MAPK.
- * Findings suggest that combining IL-10 with glucocorticoids can better restore the integrity of the intestinal lining, potentially benefiting patients who previously had limited responses to steroid treatments.