Publications by authors named "A Garcia-Alvarez"
Genomics Review of Selective RET Inhibitors Sensitivity in Thyroid Cancer Clinical Trials.
Am J Med Genet C Semin Med Genet
January 2025
RET gene is a driver of thyroid cancer (TC) tumorigenesis. The incidence of TC has increased worldwide in the last few decades, both in medullary and follicular-derived subtypes. Several drugs, including multikinase and selective inhibitors, have been explored.
View Article and Find Full Text PDFNeuroendocrine carcinomas are rare and aggressive malignancies, often diagnosed at advanced stages, leading to poor prognosis. Platinum-based chemotherapy is the standard first-line treatment for advanced neuroendocrine carcinomas; however after achieving response no consensus exists on maintenance therapies and the results are inconsistent. This review examines the role of maintenance therapy following response to first-line chemotherapy in gastroenteropancreatic neuroendocrine carcinomas.
View Article and Find Full Text PDFUnlabelled: The resumption of sexual activity (RSA) after childbirth is problematic for many women; however, it is rarely addressed as a whole in consultation with a midwife.
Objective: to describe the sexual function of women in the postpartum period and its relationship with their personal characteristics. To make a proposal adapted to their needs in conjunction with a midwife.
Article Synopsis
- - The study explored if prior experience in minimally-invasive mitral valve surgery (MIMVS) helps in learning robotic-assisted mitral valve repair among two cardiac centers.
- - Analysis of the first 62 patients in each center revealed that surgical times were significantly shorter in the center with previous MIMVS experience, but overall patient outcomes were similar.
- - The learning curve was quicker in the center with MIMVS experience, indicating it may provide an advantage in mastering robotic techniques, despite both centers eventually achieving a successful program.
: The non-canonical GC-5' splice sites (5'ss) are the most common exception (~1%) to the classical GT/AG splicing rule. They constitute weak 5'ss and can be regulated by splicing factors, so they are especially sensitive to genetic variations inducing the misrecognition of their respective exons. We aimed to investigate the GC-5'ss of the breast/ovarian cancer susceptibility genes, (exon 50), (exon 1), and (exon 12), and their dysregulation induced by DNA variants.
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