Design Principles and Applications of Fluorescent Kinase Inhibitors for Simultaneous Cancer Bioimaging and Therapy.

Kinase inhibitors are potent therapeutic agents in cancer treatment, but their effectiveness is frequently restricted by the inability to image the tumor microenvironment. To address this constraint, kinase inhibitor-fluorophore conjugates have emerged as promising theranostic agents, allowing for simultaneous cancer diagnosis and treatment. These conjugates are gaining attention for their ability to visualize malignant tissues and concurrently enhance therapeutic interventions.

Computational Exploration on Coupling Formic Acid Production with Propylene Synthesis via Catalytic Transfer Hydrogenation: The Role of beyond Reverse Water Gas Shift Reaction.

CO-assisted propane dehydrogenation (CO-ODHP) is emerging as an alternative route to the direct dehydrogenation of propane. Previous studies on CO-ODHP have shown that the role of CO is to shift the reaction equilibrium toward the product side by consuming the produced H molecules via reverse water gas shift (RWGS) reaction. Since the ultimate fate of CO is to get reduced, we herein propose another pathway of CO reduction in the realm of CO-ODHP─CO hydrogenation to formic acid (FA).

The epidemiology of eye illness in Para athletes in the Winter and Summer settings- a systematic review.

The aim of this systematic review was to evaluate eye illnesses in para athletes in the winter and summer settings. A search was conducted using PubMed-Medline, EbscoHost, and Web of Science for full-text original research articles published anytime until November 2022. Studies that reported quantitative data on eye illness in highly active individuals and para athletes, at any level of performance (elite/nonelite/recreational), aged 15-75 yrs were included.

Modulating the Energetics of C-H Bond Activation in Methane by Utilizing Metalated Porphyrinic Metal-Organic Frameworks.

In recent years, much effort has been directed toward utilizing metal-organic frameworks (MOFs) for activating C-H bonds of light alkanes. The energy demanding steps involved in the catalytic pathway are the formation of metal-oxo species and the subsequent cleavage of the C-H bonds of alkanes. With the intention of exploring the tunability of the activation barriers involved in the catalytic pathway of methane hydroxylation, we have employed density functional theory to model metalated porphyrinic MOFs (MOF-525(M)).

DBU mediated one-pot synthesis of triazolo triazines Dimroth type rearrangement.

Herein we report an efficient one-pot synthesis of [1,2,4]triazolo[1,5 ][1,3,5]triazines from commercially available substituted aryl/heteroaryl aldehydes and substituted 2-hydrazinyl-1,3,5-triazines -bromosuccinimide (NBS) mediated oxidative C-N bond formation. Isomerisation of [1,2,4]triazolo[4,3-][1,3,5]triazines to [1,2,4]triazolo[1,5-][1,3,5]triazines is driven by 1,8-diazabicyclo[5.4.