Publications by authors named "A Galeone"

Previous studies evaluated the prognostic role of hematological parameters in predicting outcome in patients with infective endocarditis (IE). However, only a few studies evaluated the role of hematological parameters in patients undergoing surgery for IE. The aim of this study was to review our 20-year experience with the treatment of native (NVE) and prosthetic (PVE) valve endocarditis and to evaluate the role of neutrophil-to-lymphocyte ratio (NLR), neutrophil-to-platelet ratio (NPR), platelet-to-lymphocyte ratio (PLR), monocyte-to-lymphocyte ratio (MLR), neutrophil-to monocyte ratio (NMR), and systemic inflammatory index (SII) on early and long-term outcomes of patients undergoing surgery for NVE and PVE.

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Thrombin binding aptamer (TBA) is one of the best-known G-quadruplex (G4)-forming aptamers that efficiently binds to thrombin, resulting in anticoagulant effects. TBA also possesses promising antiproliferative properties. As with most therapeutic oligonucleotides, chemical modifications are critical for therapeutic applications, particularly to improve thermodynamic stability, resistance in biological environment, and target affinity.

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  • Uranium is toxic and non-essential for plants, causing significant changes in Arabidopsis thaliana's root proteome when challenged with uranyl nitrate.
  • A study identified 458 proteins with altered levels, showing that uranium stress affects processes like stress response, amino acid metabolism, and cell wall reorganization.
  • The results indicate that uranium stress disrupts water flow in plants and alters transporter and metal-binding protein levels, suggesting mechanisms for mitigating uranium toxicity.
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  • Microglia play a crucial role in regulating synaptic function in the brain, but their behavior in acute brain slices may be influenced by the slicing and maintenance process.
  • In this study, researchers found that after 4 hours of slicing, microglia show morphological and functional changes, including becoming more reactive and altering their signaling capabilities.
  • The study suggests that these changes in microglia correspond to a decrease in synaptic transmission in pyramidal neurons, highlighting the importance of considering time factors in ex vivo experiments involving microglia and synaptic function.
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