Publications by authors named "A Galbiati"
Article Synopsis
- This study investigates how K-complexes (KC), a specific type of brainwave, relate to the effectiveness of Cognitive-Behavioral Therapy for Insomnia (CBT-I), which is the main treatment for chronic insomnia.
- Researchers conducted a multicenter study with 98 insomnia patients undergoing a 6-8 week CBT-I program, evaluating their sleep using polysomnography and an insomnia severity index before and after treatment.
- The results indicate that KC density, particularly its change after treatment, can predict how well patients respond to CBT-I and significantly correlates with improved sleep pressure, suggesting KC is an important biomarker for insomnia treatment.
Non-rapid eye movement (NREM) sleep parasomnias are abnormal motor and/or emotional behaviors originating from "deep" slow-wave sleep and with a multifactorial origin. The relationship between NREM parasomnias and psychopathology has been a topic of ongoing debate, but a comprehensive and systematic perspective has been lacking. This systematic review, conducted according to the preferred reporting items for systematic reviews and meta-analyses (PRISMA-P) guidelines, aims to fill this gap in the literature.
View Article and Find Full Text PDFOncoFAP is an ultrahigh affinity ligand of fibroblast activation protein (FAP), a tumor-associated antigen overexpressed in the stroma of the majority of solid tumors. OncoFAP has been previously implemented as a tumor-homing moiety for the development of small molecule drug conjugates (SMDCs). In the same context, the glycine--proline dipeptide was included with the aim to selectively undergo cleavage only in the presence of the target FAP, triggering the consequent release of the cytotoxic payload in the tumor microenvironment.
View Article and Find Full Text PDFArticle Synopsis
- The study aimed to compare manual and automated methods for detecting REM sleep without atonia (RSWA) in patients with REM sleep behavior disorder (RBD) and a control group.
- Researchers evaluated the accuracy of automated RSWA detection through in-laboratory and in-home recordings, finding high agreement with expert scoring and good reliability of results across multiple nights.
- Results showed that automated detection provided a strong ability to differentiate between RBD patients and control subjects, suggesting it could be a useful tool for diagnosing RBD.
Effect of molar dose on the in vivo tissue biodistribution profile of FAP-targeted radioligand therapeutics.
Eur J Nucl Med Mol Imaging
November 2024
Article Synopsis
- Lu-OncoFAP-23 is a new targeted treatment that shows promising effects against tumors while maintaining presence in the targeted area for a long time.
- Research was conducted on different dosages of Lu-OncoFAP-23 in mice, showing that the distribution and effectiveness depend significantly on the amount injected.
- An optimal dosage range of 90 to 250 nmol/kg was found to provide the best balance of tumor targeting while minimizing unwanted absorption in healthy organs, aiding in future clinical trial designs.