Publications by authors named "A Galan"
Article Synopsis
- Peritoneal surface oncology (PSO) focuses on understanding and managing cancerous growths in the peritoneal cavity, which can be either primary or secondary.
- There is an increasing demand for specialized training for surgical oncologists in this area to address the gap in expertise and improve patient outcomes.
- The European School of Peritoneal Surface Oncology (ESPSO) was established in 2014 to offer education and training in this emerging field.
Article Synopsis
- Researchers developed an analog of a small molecule called UM101, named GEn-1124, which has better solubility and binding affinity to the p38a MAPK protein, known for its role in inflammation.
- GEn-1124 shows significant improvements over UM101, such as an 18-fold increase in binding affinity, enhanced stability, and better lung protection, resulting in improved survival rates in mouse models of acute lung injury.
- The study reveals that GEn-1124 operates through a novel mechanism by destabilizing the p38a:MK2 complex, altering gene expression, and promoting enhanced signaling within the cell's nucleus.
Article Synopsis
- - Age-related macular degeneration (AMD) is a major cause of vision loss in older adults, and currently, there are no effective drugs to treat it.
- - Research is exploring the use of stem cells to replace damaged retinal cells, specifically targeting retinal pigment epithelium (RPE) for potential therapy.
- - This chapter reviews key clinical trials and protocols on using stem cell therapy for AMD, detailing how the progression of the disease and treatment responses have been monitored.
Background: Glaucoma is a major cause of incurable ocular morbidity and poses significant challenges in its management due to the limited treatment options and potential adverse effects. Nicotinamide, a naturally occurring diet-rich nutrient, has emerged as a promising therapeutic agent for glaucoma, offering neuroprotective effects and the potential modulation of intraocular pressure (IOP) regulation pathways. This comprehensive review sought to analyze the current literature on nicotinamide in glaucoma management, exploring its mechanisms of action, efficacy, and safety profile.
View Article and Find Full Text PDFMacrophage Migration Inhibitory Factor (MIF) and its homolog D-dopachrome Tautomerase (DDT) have been implicated as drivers of tumor progression across a variety of cancers. Recent evidence suggests MIF as a therapeutic target in immune checkpoint inhibition (ICI) resistant melanomas, however clinical evidence of MIF and particularly of DDT remain limited. This retrospective study analyzed 97 patients treated at Yale for melanoma between 2002-2020.
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