Publications by authors named "A Gabel"
Food proteins may be modified during processing and storage through reactions with reducing sugars (Maillard reaction, glycation) or by reactive oxygen species (protein oxidation). Little is known about particular reactions at the interface of glycation and oxidation. In the present study, the glycated amino acid pyrraline (6-(2-formyl-5-hydroxymethyl-1-pyrrolyl)-l-norleucine) and the proteinogenic amino acids tyrosine and tryptophan were subjected to different types of oxidation.
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- A study conducted from November 2020 to June 2023 assessed the performance of SARS-CoV-2 rapid antigen tests (RDTs) compared to standard RT-qPCR testing among a large group of patients and staff in a hospital setting.
- The analysis of nearly 78,800 paired results revealed that RDTs had a sensitivity of 34.5% and a specificity of 99.6%, with sensitivity decreasing as fewer symptomatic infections occurred over the course of the pandemic.
- The findings suggest that RDTs are still effective for diagnosing COVID-19 in symptomatic patients and could be useful for identifying other respiratory infections in the future, despite their declining sensitivity linked to vaccination and the spread of the Omicron variant
Background: Alternative polyadenylation (APA) affects most human genes and is recurrently dysregulated in all studied cancers. However, the mechanistic origins of this dysregulation are incompletely understood.
Results: We describe an unbiased analysis of molecular regulators of poly(A) site selection across The Cancer Genome Atlas and identify that colorectal adenocarcinoma is an outlier relative to all other cancer subtypes.
Article Synopsis
- * A study analyzed 77 proteins in 22 women with a history of HDP and 43 controls, finding significantly higher levels of specific CVD markers in those with HDP.
- * The study highlights the need to identify CVD biomarkers post-HDP to better assess cardiovascular risk and guide interventions for affected women.
Many of the most highly conserved elements in the human genome are "poison exons," alternatively spliced exons that contain premature termination codons and permit post-transcriptional regulation of mRNA abundance through induction of nonsense-mediated mRNA decay (NMD). Poison exons are widely assumed to be highly conserved due to their presumed importance for organismal fitness, but this functional importance has never been tested in the context of a whole organism. Here, we report that a poison exon in Smndc1 is conserved across mammals and plants and plays a molecular autoregulatory function in both kingdoms.
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