Publications by authors named "A Gaballa"
Unlabelled: Genes encoding lipid A modifying phosphoethanolamine transferases (PETs) are genetically diverse and can confer resistance to colistin and antimicrobial peptides. To better understand the functional diversity of PETs, we characterized three canonical mobile colistin resistance () alleles (, , ), one intrinsic (), and two -like genes (, ) in . Using an isogenic expression system, we show that and confer similar phenotypes of decreased colistin susceptibility with low fitness costs.
View Article and Find Full Text PDFArticle Synopsis
- AI-ECG can effectively detect hypertrophic cardiomyopathy (HCM) and track treatment responses using 12-lead ECGs.
- The study analyzed data from patients undergoing surgical reduction and those receiving mavacamten at multiple healthcare centers, finding no improvement in HCM scores after surgery, but a significant decrease in scores among patients taking mavacamten.
- This highlights AI-ECG's potential for ongoing monitoring of heart condition improvements following medication rather than surgical interventions.
Background: In hypertrophic cardiomyopathy, histologic findings like myocyte hypertrophy and disarray, interstitial fibrosis (IF), and small intramural coronary artery dysplasia (SICAD) result in left ventricular hypertrophy, diastolic dysfunction, arrhythmogenicity, and microvascular ischemia.
Objectives: The authors sought to evaluate the association between histology and outcomes in obstructive hypertrophic cardiomyopathy (oHCM) patients undergoing surgical myectomy (SM).
Methods: The study included 1,722 symptomatic oHCM patients (mean age: 56 ± 14 years; 948 [55%] men) who underwent SM at a tertiary center between 2005 and 2018.
Peracetic acid (PAA), a strong oxidizing agent, has been widely used as a disinfectant in food processing settings as it does not produce harmful chlorinated by-products. In the present study, the transcriptional response of Listeria monocytogenes to a sub-lethal concentration of PAA (2.5 ppm) was assessed using RNA-sequencing (RNA-seq).
View Article and Find Full Text PDFBackground: Apical hypertrophic cardiomyopathy (aHCM) is a distinct variant characterized by predominant hypertrophy of the left ventricle apex.
Objectives: This study sought to describe aHCM patients' characteristics and develop a risk score for aHCM patients.
Methods: A total of 462 patients (age 58 ± 15 years, 68% male) diagnosed with aHCM were included.