Striated muscles are essential for locomotion and survival. Their function and structure are highly conserved across taxa. Muscles are highly plastic.
View Article and Find Full Text PDFMechanosensitive PIEZO ion channels are evolutionarily conserved proteins that are widely expressed in neuronal and muscular tissues. This study explores the role of the mechanoreceptor PEZO-1 in the body wall muscles of , focusing on its influence on two locomotor behaviors, swimming and crawling. Using confocal imaging, we reveal that PEZO-1 localizes to the sarcolemma and plays a crucial role in modulating calcium dynamics that are important for muscle contraction.
View Article and Find Full Text PDFThe discovery in 2010 of the PIEZO family of mechanoreceptors revolutionized our understanding of the role of proprioceptive feedback in mammalian physiology. Much remains to be elucidated. This study looks at the role this receptor plays in normal locomotion.
View Article and Find Full Text PDFIntroduction: At the cellular level, acute temperature changes alter ionic conductances, ion channel kinetics, and the activity of entire neuronal circuits. This can result in severe consequences for neural function, animal behavior and survival. In poikilothermic animals, and particularly in aquatic species whose core temperature equals the surrounding water temperature, neurons experience rather rapid and wide-ranging temperature fluctuations.
View Article and Find Full Text PDFThe dynamical mechanisms underlying thermoreception in the nematode C. elegans are studied with a mathematical model for the amphid finger-like ciliated (AFD) neurons. The equations, equipped with Arrhenius temperature factors, account for the worm's thermotaxis when seeking environments at its cultivation temperature, and for the AFD's calcium dynamics when exposed to both linearly ramping and oscillatory temperature stimuli.
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